Nanotoxicity of Graphene and Graphene Oxide

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dc.contributor.authorSeabra, Amedea B. [UNIFESP]
dc.contributor.authorPaula, Amauri J.
dc.contributor.authorLima, Renata de
dc.contributor.authorAlves, Oswaldo L.
dc.contributor.authorDuran, Nelson
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Fed Ceara
dc.contributor.institutionUniv Sorocaba
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2016-01-24T14:35:16Z
dc.date.available2016-01-24T14:35:16Z
dc.date.issued2014-02-01
dc.description.abstractGraphene and its derivatives are promising candidates for important biomedical applications because of their versatility. the prospective use of graphene-based materials in a biological context requires a detailed comprehension of the toxicity of these materials. Moreover, due to the expanding applications of nanotechnology, human and environmental exposures to graphene-based nanomaterials are likely to increase in the future. Because of the potential risk factors associated with the manufacture and use of graphene-related materials, the number of nanotoxicological studies of these compounds has been increasing rapidly in the past decade. These studies have researched the effects of the nanostructural/biological interactions on different organizational levels of the living system, from biomolecules to animals. This review discusses recent results based on in vitro and in vivo cytotoxicity and genotoxicity studies of graphene-related materials and critically examines the methodologies employed to evaluate their toxicities. the environmental impact from the manipulation and application of graphene materials is also reported and discussed. Finally, this review presents mechanistic aspects of graphene toxicity in biological systems. More detailed studies aiming to investigate the toxicity of graphene-based materials and to properly associate the biological phenomenon with their chemical, structural, and morphological variations that result from several synthetic and processing possibilities are needed. Knowledge about graphene-based materials could ensure the safe application of this versatile material. Consequently, the focus of this review is to provide a source of inspiration for new nanotoxicological approaches for graphene-based materials.en
dc.description.affiliationUniversidade Federal de São Paulo, Exact & Earth Sci Dept, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Chem, Biol Chem Lab, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Phys, BR-60455900 Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Sorocaba, Dept Biotechnol, São Paulo, Brazil
dc.description.affiliationUniv Fed Sao Carlos, UFSCar, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Chem, Lab Solid State Chem, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Nat & Human Sci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Exact & Earth Sci Dept, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipLaboratory of Nanostructure Synthesis and Biosystem Interactions-NANO-BIOSS (MCTI)
dc.format.extent159-168
dc.identifierhttp://dx.doi.org/10.1021/tx400385x
dc.identifier.citationChemical Research in Toxicology. Washington: Amer Chemical Soc, v. 27, n. 2, p. 159-168, 2014.
dc.identifier.doi10.1021/tx400385x
dc.identifier.issn0893-228X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37403
dc.identifier.wosWOS:000331591400001
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofChemical Research in Toxicology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleNanotoxicity of Graphene and Graphene Oxideen
dc.typeinfo:eu-repo/semantics/article
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