Serum leptin concentration during puberty in healthy nonobese adolescents

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dc.contributor.authorBrandao, Cynthia Maria Alvares [UNIFESP]
dc.contributor.authorLombardi, Maria Tereza [UNIFESP]
dc.contributor.authorNishida, Sonia Kiyomi [UNIFESP]
dc.contributor.authorHauache, Omar Magid [UNIFESP]
dc.contributor.authorVieira, Jose Gilberto Henriques [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:30:08Z
dc.date.available2015-06-14T13:30:08Z
dc.date.issued2003-10-01
dc.description.abstractData obtained during the past five years have indicated that there are important age- and gender-based differences in the regulation and action of leptin in humans. To study the physiological changes of leptin during puberty in both sexes, and its relationship with body composition and sexual maturation, we measured leptin concentrations in 175 healthy adolescents (80 girls, 95 boys, 10-18 years of age), representing all pubertal stages. We excluded individuals with a body mass index (BMI) below the 5thor above the 95th percentile relative to age. Serum concentrations of leptin were determined by a monoclonal antibody-based immunofluorimetric assay, developed in our laboratory. Body composition was determined by dual-energy X-ray absorptiometry. Pubertal stage was assigned by physical examination, according to Tanner criteria for breast development in females and genital development in males. Leptin concentration in girls (N = 80) presented a positive linear correlation with age (r = 0.35, P = 0.0012), BMI (r = 0.65, P < 0.0001) and %fat mass (r = 0.76, P < 0.0001). In boys (N = 95) there was a positive correlation with BMI (r = 0.49, P < 0.0001) and %fat mass (r = 0.85, P < 0.0001), but a significant negative linear correlation with Tanner stage (r = -0.45, P < 0.0001) and age (r = -0.40, P < 0.0001). The regression equation revealed that %fat mass and BMI are the best parameters to be used to estimate leptin levels in both sexes. Thus, the normal reference ranges for circulating leptin during adolescence should be constructed according to BMI or %fat mass to assure a correct evaluation.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Endocrinologia
dc.description.affiliationUnifespUNIFESP, EPM, Disciplina de Endocrinologia
dc.description.sourceSciELO
dc.format.extent1293-1296
dc.identifierhttps://dx.doi.org/10.1590/S0100-879X2003001000003
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 10, p. 1293-1296, 2003.
dc.identifier.doi10.1590/S0100-879X2003001000003
dc.identifier.fileS0100-879X2003001000003.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2003001000003
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/1853
dc.identifier.wosWOS:000185906900004
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLeptinen
dc.subjectPubertal developmenten
dc.subjectBody compositionen
dc.titleSerum leptin concentration during puberty in healthy nonobese adolescentsen
dc.typeinfo:eu-repo/semantics/article
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