Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway

Página do item simplificado
dc.contributor.authorde Araujo, Orlei Ribeiro [UNIFESP]
dc.contributor.authorSalomao, Reinaldo [UNIFESP]
dc.contributor.authorColo Brunialti, Milena Karina [UNIFESP]
dc.contributor.authorBourguignon da Silva, Dafne Cardoso [UNIFESP]
dc.contributor.authorSenerchia, Andreza Almeida [UNIFESP]
dc.contributor.authorde Moraes Costa Carlesse, Fabianne Altruda [UNIFESP]
dc.contributor.authorPetrilli, Antonio Sergio [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-17T14:03:35Z
dc.date.available2020-07-17T14:03:35Z
dc.date.issued2017
dc.description.abstractBackground. The study aimed to describe the kinetics of various cytokines from day 1 to day 14 of the onset of fever in neutropenic children and to evaluate their performances as discriminators of sepsis in the first 24 hours of fever, the possible influence of filgrastim, and the functioning of the IL-23/IL-17 axis. Methods. IL-1 beta, TNF-alpha, IL-10, IL-12/23p40, IL-21, IL-6, IL-8, IL-17, G-CSF, and GM-CSF were measured in plasma on days 1, 2, 3, 5, and 14 from the onset of fever in 35 patients. Results. Thirteen patients (37.1%) developed sepsis. In mixed models, IL-6, IL-8, IL-10, and G-CSF showed higher estimated means in septic patients (P < 0 005), and IL-12/23p40 and IL-17 in nonseptic patients (P < 0 05). On day 1, IL-6, IL-8, and IL-10 appeared upregulated in patients who received filgrastim. Only IL-6, IL-8, IL-10, and procalcitonin were useful as discriminators of sepsis. Associating the markers with each other or to a risk assessment model improved performance. Conclusions. Cytokines kinetics showed proinflammatory and anti-inflammatory responses similar to what is described in nonneutropenic patients. IL-8, IL-6, IL-10, and procalcitonin are useful as early biomarkers of sepsis. Filgrastim upregulates expression of these markers, and we observed deficiency in the IL-23-IL-17 axis accompanying sepsis.en
dc.description.affiliationSao Paulo Fed Univ UNIFESP, Grp Apoio Adolescente & Crianca Canc GRAACC, IOP, Rua Pedro de Toledo 572, BR-04039001 Sao Paulo, SP, Brazil
dc.description.affiliationSao Paulo Fed Univ UNIFESP, Div Infect Dis, Dept Med, Escola Paulista Med, Rua Pedro de Toledo 669,10th Floor, BR-04039001 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespSao Paulo Fed Univ UNIFESP, Grp Apoio Adolescente & Crianca Canc GRAACC, IOP, Rua Pedro de Toledo 572, BR-04039001 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespSao Paulo Fed Univ UNIFESP, Div Infect Dis, Dept Med, Escola Paulista Med, Rua Pedro de Toledo 669,10th Floor, BR-04039001 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipGRAACC/Instituto de Oncologia Pediatrica
dc.description.sponsorshipIDFAPESP: 2011/20401-4
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1155/2017/8291316
dc.identifier.citationMediators Of Inflammation. London, v. , p. -, 2017.
dc.identifier.doi10.1155/2017/8291316
dc.identifier.fileWOS000405598300001.pdf
dc.identifier.issn0962-9351
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55518
dc.identifier.wosWOS:000405598300001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofMediators Of Inflammation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleCytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathwayen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000405598300001.pdf
Tamanho:
1.84 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos