Parvalbumin Expression and Distribution in the Hippocampal Formation of Cebus apella

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dc.contributor.authorTorres, Laila Brito [UNIFESP]
dc.contributor.authorSilva Araujo, Bruno Henrique [UNIFESP]
dc.contributor.authorMarruaz, Klena Sarges
dc.contributor.authorSouza, Janaina Sena de [UNIFESP]
dc.contributor.authorSousa, Bolivar Saldanha
dc.contributor.authorSilva, Sergio Gomes da
dc.contributor.authorCabral, Francisco Romero
dc.contributor.authorCavalheiro, Esper Abrao [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionCtr Nacl Primatas CENP
dc.contributor.institutionFac Ciencias Med Santa Casa São Paulo
dc.date.accessioned2016-01-24T14:40:18Z
dc.date.available2016-01-24T14:40:18Z
dc.date.issued2015-04-01
dc.description.abstractNew World primates play an important role in biomedical research. However, the literature still lacks information on many structural features of the brain in these species, particularly structures of the hippocampal formation that are related to long-term memory storage. This study was designed to provide information, for the first time, about the distribution and number of neurons expressing parvalbumin-immunoreactivity (PV-I) in the subregions of the hippocampal formation in Cebus apella, a New World primate species commonly used in biomedical research. Our results revealed that for several morphometric variables, PV-I cells differ significantly among the subregions CA1, CA2, CA3, and the hilus. Based upon our findings and those of other studies, we hypothesize that the proportional increase from monkeys to humans in PV-I cell density within CA1 is a factor contributing to the evolution of increased memory formation and storage. Am. J. Primatol. 77:449-461, 2015. (c) 2014 Wiley Periodicals, Inc.en
dc.description.affiliationUniversidade Federal de São Paulo, Unifesp EPM, Dept Neurol & Neurocirurgia, Lab Neurociencias, São Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Inst Cerebro, BR-05652900 São Paulo, SP, Brazil
dc.description.affiliationCtr Nacl Primatas CENP, IEC, Ananindeua, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Unifesp EPM, Dept Med, Disciplina Endocrinol Clin, São Paulo, Brazil
dc.description.affiliationFac Ciencias Med Santa Casa São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Unifesp EPM, Dept Neurol & Neurocirurgia, Lab Neurociencias, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Unifesp EPM, Dept Med, Disciplina Endocrinol Clin, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent449-461
dc.identifierhttp://dx.doi.org/10.1002/ajp.22366
dc.identifier.citationAmerican Journal of Primatology. Hoboken: Wiley-Blackwell, v. 77, n. 4, p. 449-461, 2015.
dc.identifier.doi10.1002/ajp.22366
dc.identifier.issn0275-2565
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38929
dc.identifier.wosWOS:000351688000009
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofAmerican Journal of Primatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectnew world primatesen
dc.subjectCA2 layeren
dc.subjectstereologyen
dc.subjectinhibitory interneuronsen
dc.subjectmemory storageen
dc.titleParvalbumin Expression and Distribution in the Hippocampal Formation of Cebus apellaen
dc.typeinfo:eu-repo/semantics/article
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