IMPs, VIMs and SPMs: the diversity of metallo-beta-lactamases produced by carbapenem-resistant Pseudomonas aeruginosa in a Brazilian hospital

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dc.contributor.authorSader, Helio Silva [UNIFESP]
dc.contributor.authorReis, A. O. [UNIFESP]
dc.contributor.authorSilbert, Suzane [UNIFESP]
dc.contributor.authorGales, Ana Cristina [UNIFESP]
dc.contributor.institutionJones Grp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:32Z
dc.date.available2016-01-24T12:37:32Z
dc.date.issued2005-01-01
dc.description.abstractPseudomonas aeruginosa isolates (n = 183), collected from bacteraemic patients hospitalised in São Paulo Hospital (Brazil) during 2000-2001, were screened for susceptibility to antimicrobial agents. the polymyxins were the most active compounds (100% susceptibility), followed by amikacin and cefepime (59.0%), meropenem (57.4%), and imipenem and gentamicin (55.2%). Imipenem-resistant isolates were ribotyped and screened for production of metallo-beta-lactamases (MBLs) by PCR with primers for bla(IMP), bla(VIM) and bla(SPM). MBL production was detected in 36 isolates (19.7% of the entire collection; 43.9% of the imipenem-resistant isolates) and the MBLs included SPM-1-like (55.6%), VIM-2-like (30.6%) and IMP-1-like (8.3%) enzymes.en
dc.description.affiliationJones Grp, JMI Labs, N Liberty, IA 52317 USA
dc.description.affiliationUniversidade Federal de São Paulo, Lab Alerta, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Doencas Infecciosas & Parasitarias, Lab Especial Microbiol Clin, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Lab Alerta, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Doencas Infecciosas & Parasitarias, Lab Especial Microbiol Clin, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent73-76
dc.identifierhttp://dx.doi.org/10.1111/j.1469-0691.2004.01031.x
dc.identifier.citationClinical Microbiology and Infection. Oxford: Blackwell Publishing Ltd, v. 11, n. 1, p. 73-76, 2005.
dc.identifier.doi10.1111/j.1469-0691.2004.01031.x
dc.identifier.fileWOS000226345700015.pdf
dc.identifier.issn1198-743X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28057
dc.identifier.wosWOS:000226345700015
dc.language.isoeng
dc.publisherBlackwell Publishing Ltd
dc.relation.ispartofClinical Microbiology and Infection
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcarbapenem resistanceen
dc.subjectimipenem resistanceen
dc.subjectmetallo-beta-lactamasesen
dc.subjectpolymyxinen
dc.subjectPseudomonas aeruginosaen
dc.titleIMPs, VIMs and SPMs: the diversity of metallo-beta-lactamases produced by carbapenem-resistant Pseudomonas aeruginosa in a Brazilian hospitalen
dc.typeinfo:eu-repo/semantics/article
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