Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats

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dc.citation.volume8
dc.contributor.authorFidale, Thiago Montes
dc.contributor.authorAntunes, Hanna Karen Moreira [UNIFESP]
dc.contributor.authorSantos, Luciano Alex dos
dc.contributor.authorSouza, Fernanda Rodrigues de
dc.contributor.authorDeconte, Simone Ramos
dc.contributor.authorMoura, Francyelle Borges Rosa de
dc.contributor.authorMantovani, Matheus Matioli
dc.contributor.authorAlves, Poliana Rodrigues
dc.contributor.authorRoever, Leonardo
dc.contributor.authorResende, Elmiro Santos
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.coverageLausanne
dc.date.accessioned2020-07-08T13:09:52Z
dc.date.available2020-07-08T13:09:52Z
dc.date.issued2018
dc.description.abstractCardiotoxicity is one of the most significant adverse effects of the oncologic treatment with doxorubicin, which is responsible for a substantial morbid and mortality. The occurrence of heart failure with ventricular dysfunction may lead to severe cardiomyopathy and ultimately to death. Studies have focused on the effects of leucine supplementation as a strategy to minimize or revert the clinical condition of induced proteolysis by several clinical onsets. However, the impact of leucine supplementation in heart failure induced by doxorubicin is unknown. Therefore, the objective of this work is to evaluate the effects of leucine supplementation on the cardiotoxicity in the heart of rats treated with doxorubicin. Rats treated with a 7.5 mg/kg cumulative dose of doxorubicin for 14 days presented a dilatation of the left ventricle (LV), and a reduction of the ejection fraction (FE). The 5% supplementation of leucine in the rats' food prevented the malfunctioning of the LV when administered with doxorubicin. Some alterations in the extracellular matrix remodeling were confirmed by the increase of collagen fibers in the doxorubicin group, which did not increase when the treatment was associated with leucine supplementation. Leucine attenuates heart failure in this experimental model with doxorubicin. Such protection is followed by the maintenance of interstitial collagen fibers.en
dc.description.affiliationUniv Fed Uberlandia, Lab Expt Med, Uberlandia, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Uberlandia, Inst Biomed Sci, Uberlandia, MG, Brazil
dc.description.affiliationUniv Fed Uberlandia, Veterinarian Hosp, Uberlandia, MG, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.3389/fphys.2017.01042
dc.identifier.citationFrontiers In Physiology. Lausanne, v. 8, p. -, 2018.
dc.identifier.doi10.3389/fphys.2017.01042
dc.identifier.fileWOS000422692600001.pdf
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54261
dc.identifier.wosWOS:000422692600001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDoxorubicinen
dc.subjectCardiotoxicityen
dc.subjectLeucineen
dc.subjectBCAAen
dc.subjectHeart failureen
dc.titleIncreased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Ratsen
dc.typeinfo:eu-repo/semantics/article
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