Influence of cholecalciferol (vitamin D3) on the course of experimental systemic lupus erythematosus in F1 (NZBxW) mice

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dc.contributor.authorVaisberg, Mauro Walter [UNIFESP]
dc.contributor.authorKaneno, R.
dc.contributor.authorFranco, M. F.
dc.contributor.authorMendes, N. F.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Marilia
dc.date.accessioned2016-01-24T12:30:58Z
dc.date.available2016-01-24T12:30:58Z
dc.date.issued2000-01-01
dc.description.abstractThe course of systemic lupus erythematosus (SLE), an autoimmune disease, is markedly affected by hormones such as estrogen and prolactin. It is well known that heavy exposure to sunlight has deleterious effects on SLE, triggering episodes of the disease. Classical explanations for this occurrence suggest that UV radiation damages DNA, which becomes immunogenic, or induces exposure of the Ro antigen in keratinocytes. in recent years, it has been shown that vitamin D3 has important effects on the immune system. Thus, we proposed an alternative hypothesis, suggesting that UV radiation, by promoting vitamin D3 synthesis, could be a factor aggravating the course of SLE after exposure to sunlight. To test this hypothesis, we injected F1(NZBxW) mice, which are prone to developing SLE, with vitamin D3, and we demonstrated a worsening of the histopathological findings in the kidney. (C) 2000 Wiley-liss, Inc.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Imunol, Dept Microbiol Imunol & Parasitol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Estado São Paulo, Dept Imunol, Botucatu, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Patol, São Paulo, Brazil
dc.description.affiliationUniv Marilia, Marilia, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Imunol, Dept Microbiol Imunol & Parasitol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Patol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent91-96
dc.identifierhttp://dx.doi.org/10.1002/(SICI)1098-2825(2000)14:3<91
dc.identifier.citationJournal of Clinical Laboratory Analysis. New York: Wiley-liss, v. 14, n. 3, p. 91-96, 2000.
dc.identifier.doi10.1002/(SICI)1098-2825(2000)14:3<91
dc.identifier.issn0887-8013
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26211
dc.identifier.wosWOS:000086765000002
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectlupus nephritisen
dc.subjectvitamin D3en
dc.subjecthormonesen
dc.subjectautoimmune diseaseen
dc.subjectultraviolet radiationen
dc.titleInfluence of cholecalciferol (vitamin D3) on the course of experimental systemic lupus erythematosus in F1 (NZBxW) miceen
dc.typeinfo:eu-repo/semantics/article
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