Immunologic features of HIV-1-infected women on HAART at delivery

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dc.contributor.authorOno, Erika [UNIFESP]
dc.contributor.authorDos Santos, Amelia Miyashiro [UNIFESP]
dc.contributor.authorMachado, Daisy Maria [UNIFESP]
dc.contributor.authorSucci, Regina Célia de Menezes [UNIFESP]
dc.contributor.authorAmed, Abes Mahmed [UNIFESP]
dc.contributor.authorSalomão, Reinaldo [UNIFESP]
dc.contributor.authorKallas, Esper Georges [UNIFESP]
dc.contributor.authorDe Moraes-Pinto, Maria Isabel [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:29Z
dc.date.available2016-01-24T13:51:29Z
dc.date.issued2008-07-01
dc.description.abstractBackground: the conjoint effect of HIV infection and pregnancy on the immune system of women submitted to the prophylactic antiretroviral therapy presently recommended is still poorly understood.Methods: We evaluated 44 HIV-infected women (HIV) and 45 HIV-negative women (CT) at parturition and we compared them to 20 healthy nonpregnant women (NP). Immunophenotyping of lymphocytes was done by four-color flow cytometry.Results: All HIV-infected women received HAART during pregnancy and 56.8% had viral load <50 copies/mL at delivery. CD4+T cells/mm(3) were lower in HIV (447) than CT (593) and NP (738) (P < 0.05). CD8+T cells/mm(3) were higher in HIV (799) than CT (384) and NP (395) (P < 0.05). NK cells/mm(3) were lower in HIV (146) than in CT (253) and NP (198) (P < 0.05). CD38 expression on CD4+T and on CD8+T cells was higher in HIV (CD4:12.1; CD8:14.9) than in CT(CD4:9.2; CD8:10.2) and NP(CD4:8.6; CD8:6.0) (P < 0.05). However, CD56 expression on CD8+T cells (a marker of cytolytic effector function) was lower in HIV(7%) than in CT(12%) and NP(9%) (P < 0.05).Conclusions: Even with low levels of viremia, HIV-infected women at delivery showed a different immunologic profile from both healthy non-HIV-infected women in the puerperium and nonpregnant women, with lower CD4+T and higher CD8+T cells, high levels of CD38 expression, but low CD56 expression on CD8+T cells and low NK cell numbers. (C) 2008 Clinical Cytometry Society.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Pediat Infect Dis, Res Lab, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pediat, Div Neonatol Med, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Obstet, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Infect Dis, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Pediat Infect Dis, Res Lab, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pediat, Div Neonatol Med, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Obstet, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Infect Dis, BR-04039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent236-243
dc.identifierhttp://dx.doi.org/10.1002/cyto.b.20418
dc.identifier.citationCytometry Part B-clinical Cytometry. Malden: Wiley-Blackwell, v. 74B, n. 4, p. 236-243, 2008.
dc.identifier.doi10.1002/cyto.b.20418
dc.identifier.issn1552-4949
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30739
dc.identifier.wosWOS:000256870500005
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofCytometry Part B-clinical Cytometry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectimmunophenotypingen
dc.subjectHAARTen
dc.subjectgestationen
dc.subjectHIVen
dc.titleImmunologic features of HIV-1-infected women on HAART at deliveryen
dc.typeinfo:eu-repo/semantics/article
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