Comparative genomic hybridization analysis of pediatric adamantinomatous craniopharyngiomas and a review of the literature

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dc.contributor.authorYoshimoto, Maisa
dc.contributor.authorDe Toledo, Silvia Regina Caminada
dc.contributor.authorDa Silva, Nasjla Saba
dc.contributor.authorBayani, Jane
dc.contributor.authorBertozzi, Ana Paula Antunes Pascalicchio
dc.contributor.authorStavale, João Norberto
dc.contributor.authorCavalheiro, Sergio
dc.contributor.authorAndrade, Joyce Anderson Duffles
dc.contributor.authorZielenska, Maria
dc.contributor.authorSquire, Jeremy A.
dc.contributor.institutionHosp Sick Children
dc.contributor.institutionUniv Toronto
dc.contributor.institutionOntario Canc Inst
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T18:07:30Z
dc.date.available2018-06-15T18:07:30Z
dc.date.issued2004-08-01
dc.description.abstractObject. The purpose of this study was to examine chromosomal gains and losses in 11 pediatric adamantinomatous craniopharyngiomas by using comparative genomic hybridization (CGH), as well as to review the cytogenetic literature that has contributed to the characterization of these tumors. One Source of confusion in the cytogenetic and CGH literature concerning craniopharyngioma is that the authors of most studies fail to distinguish between pediatric and later-onset forms of the disease. Thus, this study was focused on pediatric craniopharyngioma.Methods. To determine an overview of the genetic events leading to the development of these tumors, 10 adamantinomatous craniopharyngiomas were analyzed using CGH; none of the tumor specimens demonstrated gains or losses of DNA sequence.Conclusions. In view of these findings as well as those published in the majority of previous cytogenetic studies of craniopharyngiomas, the authors conclude that the recurrent acquisition of chromosomal imbalances does not play a major role in tumorigenesis and that chromosomal gains and losses are a relatively rare event in primary tumors of pediatric origin.en
dc.description.affiliationHosp Sick Children, Dept Pediat Lab Med, Toronto, ON M5G 1X8, Canada
dc.description.affiliationUniv Toronto, Toronto, ON, Canada
dc.description.affiliationOntario Canc Inst, Toronto, ON M4X 1K9, Canada
dc.description.affiliationUniv Toronto, Princess Margaret Hosp, Dept Lab Med & Pathobiol, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Princess Margaret Hosp, Dept Med Biophys, Toronto, ON, Canada
dc.description.affiliationOntario Canc Inst, Ottawa, ON, Canada
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Morphol, Div Genet, BR-04023 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Neurol, Div Neurosurg, BR-04023 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Pathol, BR-04023 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Morphol, Div Genet, BR-04023 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Neurol, Div Neurosurg, BR-04023 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Pathol, BR-04023 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent85-90
dc.identifierhttp://dx.doi.org/10.3171/ped.2004.101.2.0085
dc.identifier.citationJournal Of Neurosurgery: Pediatrics. Charlottesville: Amer Assoc Neurological Surgeons, v. 101, n. 2, p. 85-90, 2004.
dc.identifier.doi10.3171/ped.2004.101.2.0085
dc.identifier.issn0022-3085
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44522
dc.identifier.wosWOS:000223100100014
dc.language.isoeng
dc.publisherAmer Assoc Neurological Surgeons
dc.relation.ispartofJournal Of Neurosurgery
dc.rightsAcesso restrito
dc.subjectcraniopharyngiomaen
dc.subjectcytogeneticsen
dc.subjectcomparative genomic hybridizationen
dc.subjectgenetic instabilityen
dc.subjectpediatric neurosurgeryen
dc.titleComparative genomic hybridization analysis of pediatric adamantinomatous craniopharyngiomas and a review of the literatureen
dc.typeResenha
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