Effect of rosuvastatin and sevelamer on the progression of coronary artery calcification in chronic kidney disease: a pilot study

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dc.contributor.authorLemos, Marcelo M. [UNIFESP]
dc.contributor.authorWatanabe, Renato [UNIFESP]
dc.contributor.authorCarvalho, Aluizio B. [UNIFESP]
dc.contributor.authorJancikic, Alessandra D. B. [UNIFESP]
dc.contributor.authorSanches, Fabiana M. R. [UNIFESP]
dc.contributor.authorChristofalo, Dejaldo M. [UNIFESP]
dc.contributor.authorDraibe, Sergio A. [UNIFESP]
dc.contributor.authorCanziani, Maria Eugenia F. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:59Z
dc.date.available2016-01-24T14:31:59Z
dc.date.issued2013-07-01
dc.description.abstractIntroduction: Coronary artery calcification (CAC) is highly prevalent among chronic kidney disease (CKD) patients and its strong association with mortality has been recognized early in the course of CKD. the aim of the present study was to test the effect of rosuvastatin and sevelamer hydrochloride on the progression of CAC in nondialyzed CKD patients. Methods: An open-label, randomized and controlled pilot study was conducted including 117 CKD patients (62% men, 56.9 +/- 11.2 years, eGFR 36 +/- 16.5 ml/min) Patients were randomly assigned to rosuvastatin (n = 38; 10 mg/day), to sevelamer hydrochloride (n = 38; 2,400 mg/day) and to control (n = 41) groups. CAC (by multislice computed tomography) and biochemical analyses were performed at baseline and after 24 months. Results: At baseline, CAC was observed in 55%, 58% and 61% of patients in the rosuvastatin, sevelamer hydrochloride and control groups, respectively (p = 0.87). Calcium score at baseline as well as its absolute and relative changes during 24 months were similar among the groups. Low density lipoprotein cholesterol (LDL-c) was higher and decreased significantly in the rosuvastatin group (p < 0.01). the analysis adjusting for LDL-c showed that the drug regimens were not associated with the progression of CAC (drug effect p = 0.85; time-effect p < 0.001; interaction p = 0.76). Conclusions: Treatment with rosuvastatin and sevelamer hydrochloride may not delay the progression of CAC in non-dialysis dependent CKD patients.en
dc.description.affiliationUniversidade Federal de São Paulo, Hosp Rim & Hipertensao, Div Nephrol, Dept Internal Med, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Hosp Rim & Hipertensao, Dept Radiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Hosp Rim & Hipertensao, Div Nephrol, Dept Internal Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Hosp Rim & Hipertensao, Dept Radiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipGenzyme Corporation
dc.format.extent1-8
dc.identifierhttp://dx.doi.org/10.5414/CN107630
dc.identifier.citationClinical Nephrology. Deisenhofen-muenchen: Dustri-verlag Dr Karl Feistle, v. 80, n. 1, p. 1-8, 2013.
dc.identifier.doi10.5414/CN107630
dc.identifier.issn0301-0430
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36534
dc.identifier.wosWOS:000322353300001
dc.language.isoeng
dc.publisherDustri-verlag Dr Karl Feistle
dc.relation.ispartofClinical Nephrology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectvascular calcificationen
dc.subjectCKDen
dc.subjectsevelameren
dc.subjectrosuvastatinen
dc.subjectnondialysis patientsen
dc.titleEffect of rosuvastatin and sevelamer on the progression of coronary artery calcification in chronic kidney disease: a pilot studyen
dc.typeinfo:eu-repo/semantics/article
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