Histomorphometric analysis of the effects of creatine on rat myometrium

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dc.contributor.authorDo Amaral, Vinicius Cestari
dc.contributor.authorSimoes, Manuel de Jesus [UNIFESP]
dc.contributor.authorMarcondes, Rodrigo Rodrigues
dc.contributor.authorMatozinho Cubas, Jairo Jose [UNIFESP]
dc.contributor.authorBaracat, Edmund Chada
dc.contributor.authorSoares, Jose Maria [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:33Z
dc.date.available2016-01-24T14:27:33Z
dc.date.issued2012-08-01
dc.description.abstractObjective: To analyze the myometrial thickness of rats subjected to creatine (Cr) ingestion. Study design: A total of 14 rats was equally divided into the control group (ConGr) receiving 1 ml potable water and the creatine group (CrGr) subjected to the ingestion of 1.6 g/kg Cr diluted in 1 ml potable water. At the end of 8 weeks, the animals were anesthetized (xylazine and ketamine) and sacrificed, the uteri and ovaries stained with hematoxylin and eosin, the thickness of both the myometrium and the epithelium measured and the follicles counted. Results: Analysis revealed a significant increase in thickness of the myometrium in the CrGr (272.26 +/- 66.71 mu m) contrasted with that from the ConGr (160.76 +/- 35.65 mu m), CrGr > ConGr (p < 0001). Conclusion: Our data suggest that Cr changed myometrial morphology in rats by enhancing myometrial thickness, but its action mechanism in the smooth muscle is still unclear.en
dc.description.affiliationUniv São Paulo, Sch Med, Lab Struct & Mol Gynecol LIM 58, Dept Obstet & Gynecol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent587-589
dc.identifierhttp://dx.doi.org/10.3109/09513590.2011.650748
dc.identifier.citationGynecological Endocrinology. New York: Informa Healthcare, v. 28, n. 8, p. 587-589, 2012.
dc.identifier.doi10.3109/09513590.2011.650748
dc.identifier.issn0951-3590
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35165
dc.identifier.wosWOS:000306427700003
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofGynecological Endocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectCreatineen
dc.subjecthistologyen
dc.subjectmorphologyen
dc.subjectmyometriumen
dc.subjectratsen
dc.titleHistomorphometric analysis of the effects of creatine on rat myometriumen
dc.typeinfo:eu-repo/semantics/article
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