Cocristais: uma estratégia promissora na área farmacêutica

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dc.citation.issue9
dc.citation.volume39
dc.contributor.authorRocha, Alanny B. O.
dc.contributor.authorKuminek, Gislaine
dc.contributor.authorMachado, Tatiane C.
dc.contributor.authorRosa, Juliana
dc.contributor.authorRauber, Gabriela S.
dc.contributor.authorBorba, Paola A. A.
dc.contributor.authorSiedler, Sana
dc.contributor.authorStulzer, Hellen K.
dc.contributor.authorCuffini, Silvia Lucia [UNIFESP]
dc.contributor.authorRodriguez-Hornedo, Nair
dc.contributor.authorCardoso, Simone G.
dc.coverageSao Paulo
dc.date.accessioned2020-07-31T12:47:22Z
dc.date.available2020-07-31T12:47:22Z
dc.date.issued2016
dc.description.abstractPharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher than that of the constituent drug and this solubility advantage can be fine-tuned based on environmental conditions such as pH and the presence of drug solubilizing agents. This review presents a brief overview of pharmaceutical cocrystals regarding cocrystal design, obtainment methods, with particular focus on cocrystal solubility, and the solubility modulation by solution phase chemistry.en
dc.description.affiliationUniv Fed Santa Catarina, Dept Ciencias Farmaceut, BR-88040970 Florianopolis, SC, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Ciencias & Tecnol, BR-12231280 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
dc.description.affiliationUniv Cambridge, Dept Chem, Cambridge CB2 1EW, Cambs, England
dc.description.affiliationMinist Educ, CAPES, BR-70040020 Brasilia, DF, Brazil
dc.description.affiliationUnifespInstituto de Ciências e Tecnologia, Universidade Federal de São Paulo, 12231-280 São José dos Campos – SP, Brasil
dc.description.sourceWeb of Science
dc.format.extent1112-1125
dc.identifierhttp://dx.doi.org/10.21577/0100-4042.20160139
dc.identifier.citationQuimica Nova. Sao Paulo, v. 39, n. 9, p. 1112-1125, 2016.
dc.identifier.doi10.21577/0100-4042.20160139
dc.identifier.fileS0100-40422016000901112.pdf
dc.identifier.issn0100-4042
dc.identifier.scieloS0100-40422016000901112
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56777
dc.identifier.wosWOS:000390207600012
dc.language.isopor
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofQuimica Nova
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcocrystalsen
dc.subjectdrugen
dc.subjectsolubilityen
dc.subjecttransition pointen
dc.subjectthermodynamic stabilityen
dc.titleCocristais: uma estratégia promissora na área farmacêuticapt
dc.title.alternativeCocrystals: a promising strategy in pharmaceutical sciencesen
dc.typeinfo:eu-repo/semantics/article
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