Plasma Metabolomics Biosignature According to HIV Stage of Infection, Pace of Disease Progression, Viremia Level and Immunological Response to Treatment

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dc.citation.issue12
dc.citation.volume11
dc.contributor.authorScarpelini, Bruno [UNIFESP]
dc.contributor.authorZanoni, Michelle [UNIFESP]
dc.contributor.authorSucupira, Maria Cecília Araripe [UNIFESP]
dc.contributor.authorTruong, Hong-Ha M.
dc.contributor.authorJanini, Luiz Mário Ramos [UNIFESP]
dc.contributor.authorSilva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.contributor.authorDiaz, Ricardo Sobhie [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-07-31T12:47:03Z
dc.date.available2020-07-31T12:47:03Z
dc.date.issued2016
dc.description.abstractBackground We evaluated plasma samples HIV-infected individuals with different phenotypic profile among five HIV-infected elite controllers and five rapid progressors after recent HIV infection and one year later and from 10 individuals subjected to antiretroviral therapy, five of whom were immunological non-responders (INR), before and after one year of antiretroviral treatment compared to 175 samples from HIV-negative patients. A targeted quantitative tandem mass spectrometry metabolomics approach was used in order to determine plasma metabolomics biosignature that may relate to HIV infection, pace of HIV disease progression, and immunological response to treatment. Results Twenty-five unique metabolites were identified, including five metabolites that could distinguish rapid progressors and INRs at baseline. Severe deregulation in acylcarnitine and sphingomyelin metabolism compatible with mitochondrial deficiencies was observed. beta-oxidation and sphingosine-1-phosphate-phosphatase-1 activity were down-regulated, whereas acyl-alkyl-containing phosphatidylcholines and alkylglyceronephosphate synthase levels were elevated in INRs. Evidence that elite controllers harbor an inborn error of metabolism (late-onset multiple acyl-coenzyme A dehydrogenase deficiency [MADD]) was detected. Conclusions Blood-based markers from metabolomics show a very high accuracy of discriminating HIV infection between varieties of controls and have the ability to predict rapid disease progression or poor antiretroviral immunological response. These metabolites can be used as biomarkers of HIV natural evolution or treatment response and provide insight into the mechanisms of the disease.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Calif San Francisco, Dept Med, San Francisco, CA USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Microbiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo (UNIFESP), Department of Medicine, Sao Paulo—SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 04/15856-9
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0161920
dc.identifier.citationPlos One. San Francisco, v. 11, n. 12, p. -, 2016.
dc.identifier.doi10.1371/journal.pone.0161920
dc.identifier.fileWOS000392745600002.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56550
dc.identifier.wosWOS:000392745600002
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePlasma Metabolomics Biosignature According to HIV Stage of Infection, Pace of Disease Progression, Viremia Level and Immunological Response to Treatmenten
dc.typeinfo:eu-repo/semantics/article
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