Diffusion tensor imaging in autism spectrum disorders: preliminary evidence of abnormal neural connectivity

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dc.contributor.authorJou, Roger J.
dc.contributor.authorJackowski, Andrea P. [UNIFESP]
dc.contributor.authorPapademetris, Xenophon
dc.contributor.authorRajeevan, Nallakkandi
dc.contributor.authorStaib, Lawrence H.
dc.contributor.authorVolkmar, Fred R.
dc.contributor.institutionYale Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:06:10Z
dc.date.available2016-01-24T14:06:10Z
dc.date.issued2011-02-01
dc.description.abstractObjective: This study indirectly tested the hypothesis that individuals with autism spectrum disorders (ASDs) have impaired neural connections between the amygdala, fusiform face area, and superior temporal sulcus, key processing nodes of the 'social brain'. This would be evidenced by abnormalities in the major fibre tracts known to connect these structures, including the inferior longitudinal fasciculus and inferior fronto-occipital fasciculus.Method: Magnetic resonance diffusion tensor imaging was performed on 20 right-handed males (ASD = 10, controls = 10) with a mean age 13.5 +/- 4.0 years. Subjects were group-matched according to age, full-scale IQ, handedness, and ethnicity. Fractional anisotropy was used to assess structural integrity of major fibre tracts. Voxel-wise comparison of white matter fractional anisotropy was conducted between groups using ANCOVA adjusting for age, full-scale IQ, and brain volume. Volumes of interest were identified using predetermined probability and cluster thresholds. Follow-up tractography was performed to confirm the anatomic location of all volumes of interest which were observed primarily in peri-callosal regions and the temporal lobes.Results: the regions of lower fractional anisotropy, as confirmed by tractography, involved the inferior longitudinal fasciculus/inferior fronto-occipital fasciculus, superior longitudinal fasciculus, and corpus callosum/cingulum. Notably, some volumes of interest were adjacent to the fusiform face area, bilaterally, corresponding to involvement of the inferior longitudinal fasciculus. the largest effect sizes were noted for volumes of interest in the right anterior radiation of the corpus callosum/cingulum and right fusiform face area (inferior longitudinal fasciculus).Conclusions: This study provides preliminary evidence of impaired neural connectivity in the corpus callosum/cingulum and temporal lobes involving the inferior longitudinal fasciculus/inferior fronto-occipital fasciculus and superior longitudinal fasciculus in ASDs. These findings provide preliminary support for aberrant neural connectivity between the amygdala, fusiform face area, and superior temporal sulcus-temporal lobe structures critical for normal social perception and cognition.en
dc.description.affiliationYale Univ, Sch Med, Ctr Child Study, New Haven, CT 06519 USA
dc.description.affiliationYale Univ, Sch Med, Invest Med Program, New Haven, CT 06519 USA
dc.description.affiliationUniversidade Federal de São Paulo, Lab Interdiciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.affiliationYale Univ, Sch Med, Div Bioimaging Sci, Dept Diagnost Radiol, New Haven, CT 06519 USA
dc.description.affiliationYale Univ, Sch Med, Ctr Med Informat, New Haven, CT 06519 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Lab Interdiciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institute of Child Health and Human Development (NICHD)
dc.description.sponsorshipNational Institute of Neurological Disorders and Stroke (NINDS)
dc.description.sponsorshipGeneral Clinical Research Centers (GCRC)
dc.description.sponsorshipAmerican Psychiatric Institute for Research and Education/Eli Lilly and Company
dc.description.sponsorshipANA/Pfizer
dc.description.sponsorshipIDNational Institute of Child Health and Human Development (NICHD): U19-HD35482
dc.description.sponsorshipIDNational Institute of Neurological Disorders and Stroke (NINDS): R01-NS035193
dc.description.sponsorshipIDGeneral Clinical Research Centers (GCRC): MO1-RR00125
dc.format.extent153-162
dc.identifierhttp://dx.doi.org/10.3109/00048674.2010.534069
dc.identifier.citationAustralian and New Zealand Journal of Psychiatry. New York: Informa Healthcare, v. 45, n. 2, p. 153-162, 2011.
dc.identifier.doi10.3109/00048674.2010.534069
dc.identifier.issn0004-8674
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33453
dc.identifier.wosWOS:000287372000008
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofAustralian and New Zealand Journal of Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectautismen
dc.subjectconnectivityen
dc.subjectdiffusion tensor imagingen
dc.subjectsocial brainen
dc.subjectwhite matteren
dc.titleDiffusion tensor imaging in autism spectrum disorders: preliminary evidence of abnormal neural connectivityen
dc.typeinfo:eu-repo/semantics/article
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