Blockade of CTLA-4 promotes the development of effector CD8(+) T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1

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dc.contributor.authorSantos, Luara Isabela dos
dc.contributor.authorGalvao-Filho, Bruno
dc.contributor.authorFaria, Paula Cristina de
dc.contributor.authorJunqueira, Caroline
dc.contributor.authorDutra, Miriam Santos
dc.contributor.authorRibeiro Teixeira, Santuza Maria
dc.contributor.authorRodrigues, Mauricio Martins [UNIFESP]
dc.contributor.authorRitter, Gerd
dc.contributor.authorBannard, Oliver
dc.contributor.authorFearon, Douglas Thomas
dc.contributor.authorAntonelli, Lis Ribeiro
dc.contributor.authorGazzinelli, Ricardo Tostes
dc.contributor.institutionFundacao Oswaldo Cruz
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMem Sloan Kettering Canc Ctr
dc.contributor.institutionUniv Calif San Francisco
dc.contributor.institutionUniv Cambridge
dc.contributor.institutionUniv Massachusetts
dc.date.accessioned2016-01-24T14:40:08Z
dc.date.available2016-01-24T14:40:08Z
dc.date.issued2015-03-01
dc.description.abstractThe development of cancer immunotherapy has long been a challenge. Here, we report that prophylactic vaccination with a highly attenuated Trypanosoma cruzi strain expressing NY-ESO-1 (CL-14-NY-ESO-1) induces both effector memory and effector CD8(+) T lymphocytes that efficiently prevent tumor development. However, the therapeutic effect of such a vaccine is limited. We also demonstrate that blockade of Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) during vaccination enhances the frequency of NY-ESO-1-specific effector CD8(+) T cells producing IFN-gamma and promotes lymphocyte migration to the tumor infiltrate. As a result, therapy with CL-14-NY-ESO-1 together with anti-CTLA-4 is highly effective in controlling the development of an established melanoma.en
dc.description.affiliationFundacao Oswaldo Cruz, Ctr Pesquisas Rene Rachou, BR-30190002 Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Ctr Terapia Celular & Mol, BR-04044010 São Paulo, SP, Brazil
dc.description.affiliationMem Sloan Kettering Canc Ctr, New York Branch, Ludwig Inst Canc Res, New York, NY 10065 USA
dc.description.affiliationUniv Calif San Francisco, Dept Microbiol & Immunol, Howard Hughes Med Inst, San Francisco, CA 94143 USA
dc.description.affiliationUniv Cambridge, Dept Med, Sch Clin Med, Cambridge CB2 2QH, England
dc.description.affiliationUniv Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Ctr Terapia Celular & Mol, BR-04044010 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAtlantic Philanthropies/Program of Clinical Discoveries from the LICR
dc.description.sponsorshipFundacao de Amparo a Pesquisa de Minas Gerais
dc.description.sponsorshipFundacao Oswaldo Cruz
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent311-323
dc.identifierhttp://dx.doi.org/10.1007/s00262-014-1634-8
dc.identifier.citationCancer Immunology Immunotherapy. New York: Springer, v. 64, n. 3, p. 311-323, 2015.
dc.identifier.doi10.1007/s00262-014-1634-8
dc.identifier.issn0340-7004
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38810
dc.identifier.wosWOS:000350351200005
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofCancer Immunology Immunotherapy
dc.rightsAcesso restrito
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectCanceren
dc.subjectImmunotherapyen
dc.subjectNY-ESO-1en
dc.subjectAnti-CTLA-4en
dc.subjectTrypanosoma cruzien
dc.titleBlockade of CTLA-4 promotes the development of effector CD8(+) T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1en
dc.typeArtigo
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