A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents

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dc.citation.volume6
dc.contributor.authorPolonelli, Luciano
dc.contributor.authorCiociola, Tecla
dc.contributor.authorElviri, Lisa
dc.contributor.authorZanello, Pier Paolo
dc.contributor.authorGiovati, Laura
dc.contributor.authorArruda, Denise Costa [UNIFESP]
dc.contributor.authorMunoz, Julian E.
dc.contributor.authorMortara, Renato Arruda [UNIFESP]
dc.contributor.authorMorace, Giulia
dc.contributor.authorBorghi, Elisa
dc.contributor.authorGalati, Serena
dc.contributor.authorMarin, Oriano
dc.contributor.authorCasoli, Claudio
dc.contributor.authorPilotti, Elisabetta
dc.contributor.authorRonzi, Paola
dc.contributor.authorTravassos, Luiz Roberto [UNIFESP]
dc.contributor.authorMagliani, Walter
dc.contributor.authorConti, Stefania
dc.coverageLondon
dc.date.accessioned2020-07-31T12:47:33Z
dc.date.available2020-07-31T12:47:33Z
dc.date.issued2016
dc.description.abstractA phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved to exert a potent in vitro activity against fungal pathogens, and to inhibit HIV-1 replication in vitro and ex vivo. It also showed a therapeutic effect against an experimental infection by Candida albicans in the invertebrate model Galleria mellonella. K40H represents the proof of concept of the innate role that naturally occurring antibody fragments may exert against infectious agents, shedding a new light upon the posthumous role of antibodies and opening a new scenario on the multifaceted functionality of humoral immunity.en
dc.description.affiliationUniv Parma, Dept Biomed Biotechnol & Translat Sci, Microbiol & Virol Unit, Parma, Italy
dc.description.affiliationUniv Parma, Dept Pharm, Parma, Italy
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Expt Oncol Unit, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Microbiol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, Brazil
dc.description.affiliationUniv Milan, Dept Hlth Sci, Milan, Italy
dc.description.affiliationUniv Parma, Dept Life Sci, Parma, Italy
dc.description.affiliationUniv Padua, Dept Biomed Sci, Padua, Italy
dc.description.affiliationUniv Milan, L Sacco Dept Biomed & Clin Sci, Milan, Italy
dc.description.affiliationCtr Med Res & Mol Diagnost, GEMIB Lab, Parma, Italy
dc.description.affiliationUnifespExperimental Oncology Unit, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1038/srep35018
dc.identifier.citationScientific Reports. London, v. 6, p. -, 2016.
dc.identifier.doi10.1038/srep35018
dc.identifier.fileWOS000385063800001.pdf
dc.identifier.issn2045-2322
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56907
dc.identifier.wosWOS:000385063800001
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleA Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agentsen
dc.typeinfo:eu-repo/semantics/article
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