Factors associated with the time to the first wheezing episode in infants: a cross-sectional study from the International Study of Wheezing in Infants (EISL)

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dc.citation.volume26
dc.contributor.authorPacheco-Gonzalez, Rosa M.
dc.contributor.authorMallol, Javier
dc.contributor.authorSole, Dirceu [UNIFESP]
dc.contributor.authorBrand, Paul L. P.
dc.contributor.authorPerez-Fernandez, Virginia
dc.contributor.authorSanchez-Solis, Manuel
dc.contributor.authorGarcia-Marcos, Luis
dc.coverageNew York
dc.date.accessioned2020-11-03T14:40:40Z
dc.date.available2020-11-03T14:40:40Z
dc.date.issued2016
dc.description.abstractMale gender, asthmatic heredity, perinatal tobacco smoke exposure and respiratory infections have been associated with wheeze in the first years of life, among other risk factors. However, information about what factors modify the time to the first episode of wheeze in infants is lacking. The present study analyses which factors are associated with shorter time to the first episode of wheeze in infants. Parents of 11- to 24-month-old children were surveyed when attending their health-care centres for a control visit. They answered a questionnaire including the age in months when a first wheeze episode (if any) had occurred (outcome variable). The study was performed in 14 centres in Latin America (LA) and in 8 centres in Europe (EU) (at least 1,000 infants per centre). Factors known to be associated with wheezing in the cohort were included in a survival analysis (Cox proportional hazards model). Summary hazard ratios adjusted for all risk factors (aHR) were calculated using the meta-analysis approach with random effects. A total of 15,067 infants had experienced wheezing at least once, out of 35,049 surveyed. Male gender in LA (aHR 1.05, 95% confidence interval (CI) 1.00-1.10, P = 0.047), parental asthma in LA and EU (aHR 1.05, 95% CI 1.00-1.11, P = 0.037), infant eczema in EU (aHR 1.25, 95% CI 1.12-1.39, P < 0.001) and having a cold during the first 3 months in LA and EU (aHR 1.97, 95% CI 1.90-2.04, P < 0.001), in LA (aHR 1.98, 95% CI 1.90-2.06, P < 0.001) and in EU (aHR 1.91, 95% CI 1.75-2.09, P < 0.001) were associated with a shorter period of time to the first episode. Breast feeding for at least 3 months was associated with a longer period, only in LA (aHR 0.91, 95% CI 0.86-0.96, P < 0.001). Cold symptoms during the first 3 months is the most consistent factor shortening the time to the first episode of wheezing; breast feeding for >= 3 months delays it only in LA, whereas eczema shortens it only in EU. Avoiding a common cold in the first months of life could be a good strategy to delay the first wheeze episode; however, cohort studies will help to elucidate this association.en
dc.description.affiliationUniv Murcia, Virgen de la Arrixaca Univ Childrens Hosp, Pediat Resp & Allergy Unit, Murcia, Spain
dc.description.affiliationUniv Santiago Chile USACH, Dept Pediat Resp Med, Hosp El Pino, Santiago, Chile
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, Sao Paulo, Brazil
dc.description.affiliationIsala Klin, Princess Amalia Childrens Clin, Zwolle, Netherlands
dc.description.affiliationUniv Med Ctr Groningen, UMCG Postgrad Sch Med, NL-9713 AV Groningen, Netherlands
dc.description.affiliationUniv Murcia, Dept Pediat, Murcia, Spain
dc.description.affiliationIMIB Biores Inst, Murcia, Spain
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSpanish 'Fondo de Investigacion Sanitaria'
dc.description.sponsorship'Secretaria de Estado para la Cooperacion Internacional'
dc.description.sponsorshipRegional Government of Murcia, Spain
dc.description.sponsorshipFoundation to Combat Asthma (Stichting Astmabestrijding), Amsterdam, The Netherlands
dc.description.sponsorshipIDSpanish 'Fondo de Investigacion Sanitaria': PI050480
dc.description.sponsorshipID'Secretaria de Estado para la Cooperacion Internacional': A/3069/05
dc.description.sponsorshipID'Secretaria de Estado para la Cooperacion Internacional': A/5189/06
dc.format.extent-
dc.identifierhttps://doi.org/10.1038/npjpcrm.2015.77
dc.identifier.citationNpj Primary Care Respiratory Medicine. New York, v. 26, p. -, 2016.
dc.identifier.doi10.1038/npjpcrm.2015.77
dc.identifier.fileWOS000368548000001.pdf
dc.identifier.issn2055-1010
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58679
dc.identifier.wosWOS:000368548000001
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofNpj Primary Care Respiratory Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleFactors associated with the time to the first wheezing episode in infants: a cross-sectional study from the International Study of Wheezing in Infants (EISL)en
dc.typeinfo:eu-repo/semantics/article
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