Effects of paradoxical sleep deprivation and cocaine on genital reflexes in hyperlipidic-fed rats

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dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorD'Almeida, Vânia [UNIFESP]
dc.contributor.authorMartins, Paulo José Forcina [UNIFESP]
dc.contributor.authorAntunes, Hanna Karen Moreira [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:38:00Z
dc.date.available2016-01-24T12:38:00Z
dc.date.issued2005-08-01
dc.description.abstractThe present study was designed to investigate the effects of a hyperlipidic diet (HD) on penile erection (PE) and ejaculation (EJ) induced by cocaine in paradoxical sleep deprived (PSD) rats. Secondly, we aimed to verify the influence of HD cafeteria diet on steroid hormone levels. Twenty-one day-old male Wistar rats were randomly assigned into two groups: rats fed with commercial chow diet and rats fed with a palatable HD containing chow mixed with peanuts, milk chocolate and sweet cookies in the proportion of 3:2:2:1. After nine weeks of treatment, the animals were submitted to PSD or maintained as home cage control group for 96 h and challenged with cocaine (7 mg/kg, ip). Results showed that the HD led to a reduction in the frequency of erection in the PSD+cocaine group when compared to the PSD+cocaine fed with standard diet. Regardless of the diet, testosterone concentrations were significantly lower and progesterone was higher in the PSD rats than in the respective home-cage control rats. Although there were no hormonal alterations, the findings showed that a long-term HD might modify the stimulating effects of cocaine in potentiating genital reflexes in PSD rats. (c) 2005 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychol, Escola Paulista Med, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, CEPE, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychol, Escola Paulista Med, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, CEPE, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent758-763
dc.identifierhttps://dx.doi.org/10.1016/j.pbb.2005.05.012
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 81, n. 4, p. 758-763, 2005.
dc.identifier.doi10.1016/j.pbb.2005.05.012
dc.identifier.issn0091-3057
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/28410
dc.identifier.wosWOS:000231922500008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectParadoxical sleep deprivationen
dc.subjectHyperlipidic dieten
dc.subjectGenital reflexesen
dc.subjectCocaineen
dc.subjectTestosteroneen
dc.subjectProgesteroneen
dc.titleEffects of paradoxical sleep deprivation and cocaine on genital reflexes in hyperlipidic-fed ratsen
dc.typeinfo:eu-repo/semantics/article
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