The effect of phenylephrine and cyclopentolate on objective wavefront measurements

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dc.contributor.authorJankov, Mirko R.
dc.contributor.authorIseli, Hans Peter
dc.contributor.authorBueeler, Michael
dc.contributor.authorSchor, Paulo
dc.contributor.authorSeiler, Theo
dc.contributor.authorMrochen, Michael
dc.contributor.institutionMilos Clin Eye Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Refract & Ophthalm Surg
dc.contributor.institutionSwiss Fed Inst Technol
dc.date.accessioned2018-06-15T18:11:05Z
dc.date.available2018-06-15T18:11:05Z
dc.date.issued2006-05-01
dc.description.abstractPURPOSE: To investigate the impact of phenylephrine and cyclopentolate on wavefront refraction and fourth order spherical aberration C(12).METHODS: This cohort study comprised 151 eyes with sphere up to -10.00 diopters (D) and cylinder -3.75 D. Aberrometry was performed using the ALLEGRO WAVE (WaveLight Laser Technologies AG, Erlangen, Germany) after instillation of phenylephrine 5% yielding objective phenylephrine refraction in accommodated steady-state, as well as after cyclopentolate 0.5% providing objective cyclopentolate refraction in non-accommodated state. Accommodation target fogging was turned off. Wavefront aberrations were expressed by Zemike expansion up to the sixth order, and paraxial curvature matching with Taylor series was used to calculate objective wavefront sphere.RESULTS: Objective wavefront sphere was not influenced by pupil size. Eyes showed substantial accommodation after phenylephrine with a myopic shift of -0.66 D comparing objective to subjective manifest sphere (r=0.942, P<.001). Cycloplegic eyes behaved like a model eye, with a difference of -0.08 D between objective and subjective cycloplegic sphere (r=0.976, P<.001). C(12) increased ten-fold from 4.0- to 7.0-mm pupil size, keeping the same sign. Comparing cyclopentolate with phenylephrine, the sign of C(12) changed in a positive direction by an average +0.124 +/- 0.109 mu m (range: -0.052 to +0.632 mu m) at 7.0 mm, whereas the total higher order aberrations changed very little. A good correlation was found between C(12) and the change in objective wavefront sphere between cyclopentolate and phenylephrine (r=0.75, P<.001).CONCLUSIONS: Fogging of the accommodation target should be used for wavefront measurements. Weaker cycloplegic agents, such as tropicamide, may be used to ensure relaxed but not completely paralyzed accommodation, which would yield manifest aberration values close to the natural resting state.en
dc.description.affiliationMilos Clin Eye Hosp, Belgrade 11000, Serbia Monteneg
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Inst Visao, Sao Paulo, Brazil
dc.description.affiliationInst Refract & Ophthalm Surg, Zurich, Switzerland
dc.description.affiliationSwiss Fed Inst Technol, Zurich, Switzerland
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Inst Visao, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent472-481
dc.identifierhttp://dx.doi.org/10.3928/1081-597X-20060501-09
dc.identifier.citationJournal Of Refractive Surgery. Thorofare: Slack Inc, v. 22, n. 5, p. 472-481, 2006.
dc.identifier.doi10.3928/1081-597X-20060501-09
dc.identifier.issn1081-597X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44615
dc.identifier.wosWOS:000237429400010
dc.language.isoeng
dc.publisherSlack Inc
dc.relation.ispartofJournal Of Refractive Surgery
dc.rightsAcesso restrito
dc.titleThe effect of phenylephrine and cyclopentolate on objective wavefront measurementsen
dc.typeArtigo
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