Genetic variants in gastric cancer: Risks and clinical implications

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dc.contributor.authorGigek, Carolina Oliveira [UNIFESP]
dc.contributor.authorCalcagno, Danielle Queiroz
dc.contributor.authorRasmussen, Lucas Trevizani
dc.contributor.authorSantos, Leonardo Caires [UNIFESP]
dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorWisnieski, Fernanda [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodriguez
dc.contributor.authorLourenco, Laercio Gomes [UNIFESP]
dc.contributor.authorLopes-Filho, Gaspar Jesus [UNIFESP]
dc.contributor.authorCardoso Smith, Marilia Arruda [UNIFESP]
dc.date.accessioned2019-08-19T11:49:59Z
dc.date.available2019-08-19T11:49:59Z
dc.date.issued2017
dc.description.abstractCancer is a multifactorial disease that involves many molecular alterations. Gastric cancer (GC) is the third leading cause of cancer death worldwide. GC is a highly heterogeneous disease with different molecular and genetics features. Therefore, this review focuses on an overview of the genetic aspects of gastric cancer by highlighting the important impact and role of deletions and/or duplications of chromosomal segments, genomic variants, H. pylori infection and interleukin variants, as found in gene expression and newly proposed molecular classification studies. The challenge is to better understand the mechanisms and different pathways that lead to the development and progression of GC.en
dc.description.affiliationUniv Fed São Paulo UNIFESP, Dept Morfol & Genet, Disciplina Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Fed São Paulo UNIFESP, Disciplina Gastroenterol Cirurg, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Fed Para UEPA, Nucl Pesquisas Oncol, BR-66073000 Belem, Para, Brazil
dc.description.affiliationUniv Sagrado Coracao, Proreitoria Pesquisa & Posgrad, BR-17011116 Bauru, Brazil
dc.description.affiliationUniv Fed São Paulo UNIFESP, Dept Ortopedia & Traumatol, BR-04038032 São Paulo, Brazil
dc.description.affiliationHosp Ophir Loyola, Lab Biol Mol, BR-66060281 Belem, Para, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo UNIFESP, Dept Morfol & Genet, Disciplina Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo UNIFESP, Disciplina Gastroenterol Cirurg, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo UNIFESP, Dept Ortopedia & Traumatol, BR-04038032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESp: 2011/22548-2
dc.description.sponsorshipIDFAPESP: 2012/14768-5
dc.description.sponsorshipIDFAPESP: 2016/19953-6
dc.description.sponsorshipIDCNPq: 305220/2013-6
dc.description.sponsorshipIDCNPq: 303871/2014-8
dc.format.extent101-111
dc.identifierhttp://dx.doi.org/10.1016/j.yexmp.2017.07.004
dc.identifier.citationExperimental And Molecular Pathology. San Diego, v. 103, n. 1, p. 101-111, 2017.
dc.identifier.doi10.1016/j.yexmp.2017.07.004
dc.identifier.issn0014-4800
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51449
dc.identifier.wosWOS:000408182800015
dc.language.isoeng
dc.publisherAcademic Press Inc Elsevier Science
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectGastric canceren
dc.subjectCNVen
dc.subjectGWASen
dc.subjectPolymorphismen
dc.subjectInterleukinen
dc.subjectmRNA expressionen
dc.titleGenetic variants in gastric cancer: Risks and clinical implicationsen
dc.typeinfo:eu-repo/semantics/review
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