MODULATION of HALOPERIDOL-INDUCED CATALEPSY in RATS BY GABAERGIC NEURAL SUBSTRATE in the INFERIOR COLLICULUS

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dc.contributor.authorTostes, J. G.
dc.contributor.authorMedeiros, P. [UNIFESP]
dc.contributor.authorMelo-Thomas, L. [UNIFESP]
dc.contributor.institutionUniv Sao Francisco
dc.contributor.institutionFac Med Itajuba
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Neurociencias & Comportamento INEC
dc.date.accessioned2016-01-24T14:34:52Z
dc.date.available2016-01-24T14:34:52Z
dc.date.issued2013-12-26
dc.description.abstractNot only is the inferior colliculus (IC) a highly important center of integration within the central auditory pathway, but it may also play a modulatory role in sensorymotor circuitry. Previous evidence from our laboratory relating the IC to motor behavior shows that glutamate-mediated mechanisms within the IC modulate haloperidol-induced catalepsy. the high density of GABAergic receptors in the IC led to this study of a possible link between these receptors, haloperidol-induced catalepsy, and a possible involvement of the blockade of dopaminergic receptors. Catalepsy was evaluated by positioning both forepaws of rats on an elevated horizontal wooden bar and recording the time that the animal maintained this position. the present study shows that haloperidol-induced catalepsy was enhanced by local microinjection into the IC of midazolam (20 nmol/0.5 mu l), a benzodiazepine receptor agonist, whereas animals receiving a microinjection of bicuculline (40 or 80 ng/0.5 mu l), a GABAergic antagonist, showed a reduction in the time of catalepsy. However, the microinjection of haloperidol (2.5 or 5.0 mu g/0.5 mu l) bilaterally into the IC did not induce catalepsy. Therefore, our results suggest the involvement of the IC in the modulation of catalepsy induced by haloperidol, even though the dopaminergic mechanisms of the IC are unable to induce catalepsy when blocked by the direct microinjection of haloperidol. It is thus possible that the IC plays a role in sensorimotor gating and that GABA-mediated mechanisms are involved. (C) 2013 IBRO. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Sao Francisco, Lab Neuropsicofarmacol, BR-12916900 Braganca Paulista, SP, Brazil
dc.description.affiliationFac Med Itajuba, BR-37502138 Itajuba, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationInst Neurociencias & Comportamento INEC, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2009/01437-8
dc.description.sponsorshipIDFAPESP: 2011/01409-4
dc.format.extent212-218
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2013.09.064
dc.identifier.citationNeuroscience. Oxford: Pergamon-Elsevier B.V., v. 255, p. 212-218, 2013.
dc.identifier.doi10.1016/j.neuroscience.2013.09.064
dc.identifier.issn0306-4522
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37091
dc.identifier.wosWOS:000330591500018
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjecthaloperidolen
dc.subjectcatalepsyen
dc.subjectGABAen
dc.subjectmidazolamen
dc.subjectbicucullineen
dc.subjectinferior colliculusen
dc.titleMODULATION of HALOPERIDOL-INDUCED CATALEPSY in RATS BY GABAERGIC NEURAL SUBSTRATE in the INFERIOR COLLICULUSen
dc.typeinfo:eu-repo/semantics/article
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