Morphine attenuates the expression of sensitization to ethanol, but opioid antagonists do not

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dc.contributor.authorAbrahao, Karina Possa [UNIFESP]
dc.contributor.authorQuadros, I. M.
dc.contributor.authorSouza-Formigoni, M. L. O. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionTufts Univ
dc.date.accessioned2016-01-24T13:51:46Z
dc.date.available2016-01-24T13:51:46Z
dc.date.issued2008-10-28
dc.description.abstractBehavioral sensitization to ethanol is characterized by an increased locomotor activity after repeated exposure. A great variability exists among species and strains in the development of sensitization. There is a growing amount of evidence to indicate that the opioid system is involved in alcoholism; it is possible, therefore, that this system also modulates the sensitization to ethanol. in this study we evaluated the role of the opioid system in determining the variability of the sensitized response to ethanol. Mice received repeated administrations of ethanol (2.2 g/kg) or saline every other day for 10 days. According to their locomotor response on the last day of treatment, ethanol-treated animals were classified into two groups: sensitized or non-sensitized mice. After the treatment, mice were submitted to four challenges 48 h apart. in experiments 1 and 2, mice were challenged, respectively, with i.p. administration of opioid antagonists (naloxone or naltrexone) or an opioid agonist (morphine), followed immediately by 2.2 g/kg ethanol. in experiment 3, animals received morphine by i.c.v., followed by 2.2 g/kg of ethanol (i.p.). Pretreatment with opioid antagonists (naloxone or naltrexone) did not block the expression of ethanol sensitization; however pretreatment with morphine attenuated the increased locomotor activity after ethanol administration in sensitized mice. in experiment 4, after the ethanol or saline treatment, mice brains were processed and brain mu opioid binding was assessed by autoradiography using [3H]D-Ala2,N-mePhe4, Gly-ol5-enkephalin ([3H]DAMGO). No differences were seen between any of the groups of mice, so the agonist effect is not likely to be mediated by differences in binding to mu opioid receptors. (C) 2008 IBRO. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationTufts Univ, Dept Psychol, Boston, MA 02111 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipthe Associacao Fundo Incentivo a Psicofarmalogia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent857-864
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2008.08.012
dc.identifier.citationNeuroscience. Oxford: Pergamon-Elsevier B.V., v. 156, n. 4, p. 857-864, 2008.
dc.identifier.doi10.1016/j.neuroscience.2008.08.012
dc.identifier.issn0306-4522
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30972
dc.identifier.wosWOS:000260596000005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectnaloxoneen
dc.subjectnaltrexoneen
dc.subjectmorphineen
dc.subjectlocomotor activityen
dc.subjectmiceen
dc.subjectautoradiographyen
dc.titleMorphine attenuates the expression of sensitization to ethanol, but opioid antagonists do noten
dc.typeinfo:eu-repo/semantics/article
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