Collection time of Thyroid hormones and TSH in preterm newborns

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Moraes, Simone Holzer de
Espiridião, Silvia [UNIFESP]
Fonseca, Fernando Luiz Affonso [UNIFESP]
Abreu, Luiz Carlos de [UNIFESP]
Valenti, Vitor Engrácia [UNIFESP]
Souto, Ricardo Peres do
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Background: In this study we aimed to evaluate the collection time of T3, free T4 and TSH in preterm newborns.Methods: Prospective study, composed of 85 preterm newborns (PTI) as the gestational age stratified into four groups: Group A: n = 18 (less than 30 weeks); Group B: n = 13 (30 + 1 / 7-32 weeks); Group C: n = 19 (32 + 1 / 7 to 34 weeks) and; Group D: n = 35 (34 + 1 / 7 to 36 weeks). The collections of T3, T4 and thyroid stimulating hormone (TSH) were collected by chemiluminescence in six stages: 1 - umbilical cord; 2 - 3 days old; 3 - 7 days old; 4 - 14 days old; 5 - 30 days old and; 6 - 60 days old.Results: We observed significant differences until the dosage of 30 days, for free T4 between groups A and D; for the T3 between A and B groups with C and D groups. In the comparison between the times the time 1 was significantly different for TSH and T3.Conclusion: The hormone levels are gradually lower the lower the gestational age and the minimum ideal time for the collection of tests is from the 3(rd) day of life for TSH and the 7(th) day to the T4 and T3.
Healthmed. Sarajevo: Drunpp-sarajevo, v. 5, n. 3, p. 627-632, 2011.