Temporal evolution of carbapenem-resistant Acinetobacter baumannii in Curitiba, southern Brazil

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dc.contributor.authorSchimith, Karina Eugenia
dc.contributor.authorLuiz, Simone Oliveira
dc.contributor.authorScheffer, Mara Cristina
dc.contributor.authorGales, Ana Cristina [UNIFESP]
dc.contributor.authorPaganini, Maria Cristina
dc.contributor.authorNascimento, Agnaldo Jose do
dc.contributor.authorCarignano, Evelyn
dc.contributor.authorDalla Costa, Libera Maria
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Tuiuti Parana
dc.contributor.institutionPequeno Principe Coll Pele Pequeno Res Inst FPP I
dc.date.accessioned2016-01-24T13:59:38Z
dc.date.available2016-01-24T13:59:38Z
dc.date.issued2010-05-01
dc.description.abstractBackground: in the last few years, carbapenem-resistant Acinetobacter baumannii isolates (CR-AB) have been identified worldwide. the first description of OXA-23-producing A baumannii in Brazil was from the city of Curitiba in 2003. the aim of the present study was to evaluate the persistence and dissemination of the first OXA-23-producing A baumannii clone isolated from patients in Hospital de Clinicas, Curitiba, Brazil.Methods: An antimicrobial susceptibility profile of the isolates was determined by the standard agar dilution method. Molecular detection of beta-lactamase genes was done by polymerase chain reaction. the clonal relationship of the isolates was analyzed by pulsed-field gel electrophoresis (PFGE). Epidemiologic and clinical features were evaluated as well.Results: Genotypic analysis of 172 CR-AB isolates by PFGE identified 3 distinct major PFGE clusters (A, B, and C, accounting for 36, 69, and 65 isolates, respectively). All isolates carried the bla(OXA-23)-like gene and were multidrug-resistant, but were susceptible to tigecycline and polymixin B. the mortality rate related to CR-AB infection was 45.4%, and ventilator-associated pneumonia and bloodstream infections were the most frequent clinical manifestations.Conclusions: the presence of 3 clones among the CR-AB isolates suggests that cross-transmission was the main mechanism responsible for dissemination of OXA-23 producers. PFGE pattern A was genotypically similar to that of the first OXA-23-producing A baumannii clone identified in Curitiba in 1999. This clone persisted in the same hospital until April 2004. the presence of the bla(OXA-23)-like gene was the main mechanism associated with carbapenem resistance among the isolates studied.en
dc.description.affiliationUFPR, Hosp Clin, Bacteriol Lab, UAD, BR-80060240 Curitiba, Parana, Brazil
dc.description.affiliationUFPR, Microbiol Parasitol & Pathol Postgrad Program, BR-80060240 Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Santa Catarina, Clin Hosp, Florianopolis, SC, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Infect Dis, São Paulo, Brazil
dc.description.affiliationUniv Tuiuti Parana, Curitiba, Parana, Brazil
dc.description.affiliationUFPR, Pharmaceut Sci Postgrad Program, BR-80060240 Curitiba, Parana, Brazil
dc.description.affiliationPequeno Principe Coll Pele Pequeno Res Inst FPP I, Curitiba, Parana, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Infect Dis, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBrazilian National Council for Scientific and Technological Development
dc.description.sponsorshipMinistry of Science and Technology
dc.description.sponsorshipJanssen Cylag
dc.description.sponsorshipNovartis
dc.description.sponsorshipSanofi-Aventis
dc.description.sponsorshipWyeth
dc.description.sponsorshipIDMinistry of Science and Technology: 307714/2006-3
dc.format.extent308-314
dc.identifierhttp://dx.doi.org/10.1016/j.ajic.2009.09.012
dc.identifier.citationAmerican Journal of Infection Control. New York: Mosby-Elsevier, v. 38, n. 4, p. 308-314, 2010.
dc.identifier.doi10.1016/j.ajic.2009.09.012
dc.identifier.issn0196-6553
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32507
dc.identifier.wosWOS:000276979600009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAmerican Journal of Infection Control
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAcinetobacter baumanniien
dc.subjectcarbapenem resistanceen
dc.subjectOXA-23en
dc.titleTemporal evolution of carbapenem-resistant Acinetobacter baumannii in Curitiba, southern Brazilen
dc.typeinfo:eu-repo/semantics/article
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