EFFECTS OF PARATHYROID-HORMONE ON URINARY ACIDIFICATION IN THE RAT

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dc.contributor.authorGil, Frida Zaladek [UNIFESP]
dc.contributor.authorCostasilva, V. L.
dc.contributor.authorMalnic, G.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T14:28:00Z
dc.date.available2018-06-15T14:28:00Z
dc.date.issued1991-01-01
dc.description.abstractTo evaluate the effects of parathyroid hormone (PTH) on urinary acidification parameters, thyroparathyroidectomy was performed in normal (TPTX) and in calcium-supplemented rats (TPTX+Ca2+). Both groups were supplemented with thyroxin. Glomerular filtration rate (GFR) fell from 7.79 +/- 0.33 in the control group (C) to 4.88 +/- 0.26 ml min-1 kg-1 in TPTX, while net acid excretion fell from 5.65 +/- 0.22 in C to 3.76 +/- 0.25-mu-mol min-1 kg-1 in TPTX. Kinetic data of urinary acidification obtained by microperfusion techniques in proximal tubules showed that the half-time of acidification (t/2) rose from 4.75 +/- 0.24 s in C to 8.97 +/- 0.64 s in TPTX and persisted elevated in TPTX+Ca2+ (7.40 +/- 0.43 s); in the latter group, stationary pH was not significantly different from that of the control group. Bicarbonate reabsorption (J(HCO3)) fell from 2.18 +/- 0.15 in C to 0.823 +/- 0.082 in TPTX and was 1.53 +/- 0.073 nmol s-1 cm-2 in TPTX+Ca2+. These data suggest that normal pH gradients depend on normal calcium levels, but acidification half-times are dependent on PTH, which also contributes to keeping glomerular hemodynamics and acidification rates at normal levels.en
dc.description.affiliationUNIV SAO PAULO,INST CIENCIAS BIOMED,DEPT FISIOL & BIOFIS,FISIOL RENAL LAB,BR-05508 SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent1063-1066
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 24, n. 10, p. 1063-1066, 1991.
dc.identifier.issn0100-879X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42998
dc.identifier.wosWOS:A1991GR20300013
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.rightsAcesso restrito
dc.subjectPARATHYROID HORMONEen
dc.subjectURINARY ACIDIFICATIONen
dc.subjectTHYROPARATHYROIDECTOMYen
dc.subjectGLOMERULAR FILTRATION RATEen
dc.titleEFFECTS OF PARATHYROID-HORMONE ON URINARY ACIDIFICATION IN THE RATen
dc.typeArtigo
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