Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise

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dc.contributor.authorBernardes, Danielle
dc.contributor.authorOliveira-Lima, Onesia Cristina
dc.contributor.authorSilva, Thiago Vitarelli da
dc.contributor.authorFaraco, Camila Cristina Fraga
dc.contributor.authorLeite, Hercules Ribeiro
dc.contributor.authorJuliano, Maria Aparecida [UNIFESP]
dc.contributor.authorSantos, Daniel Moreira dos
dc.contributor.authorBethea, John R.
dc.contributor.authorBrambilla, Roberta
dc.contributor.authorOrian, Jacqueline M.
dc.contributor.authorArantes, Rosa Maria Esteves
dc.contributor.authorCarvalho-Tavares, Juliana
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionMinist Educ Brazil
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Miami
dc.contributor.institutionLa Trobe Univ
dc.date.accessioned2016-01-24T14:34:43Z
dc.date.available2016-01-24T14:34:43Z
dc.date.issued2013-11-15
dc.description.abstractThe interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. in the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, and the clinical score was attenuated. Although, the cytokine levels were decreased in the brain and increased in the spinal cord, BDNF was elevated in both compartments with a tendency of lesser demyelization volume in the spinal cord of the exercised EAE group compared with the unexercised. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, Nucleo Neurociencias, BR-31270901 Belo Horizonte, MG, Brazil
dc.description.affiliationMinist Educ Brazil, CAPES Fdn, Programa Pos Grad Ciencias Biol Fisiol Farmacol, BR-70040020 Brasilia, DF, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Patol, BR-31270901 Belo Horizonte, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biofis, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Lab Venenos & Toxinas Anim, BR-31270901 Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA
dc.description.affiliationLa Trobe Univ, Dept Biochem, Bundoora, Vic 3086, Australia
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biofis, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipNIH
dc.description.sponsorshipIDCAPES: BEX 0020/12-5
dc.description.sponsorshipIDNIH: NS051709
dc.description.sponsorshipIDNIH: NS065479
dc.description.sponsorshipIDFAPEMIG: CBB-APQ-01459-10
dc.description.sponsorshipIDFAPEMIG: PPM-00200-12
dc.format.extent24-34
dc.identifierhttps://dx.doi.org/10.1016/j.jneuroim.2013.08.014
dc.identifier.citationJournal of Neuroimmunology. Amsterdam: Elsevier B.V., v. 264, n. 1-2, p. 24-34, 2013.
dc.identifier.doi10.1016/j.jneuroim.2013.08.014
dc.identifier.fileWOS000327567700004.pdf
dc.identifier.issn0165-5728
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/36978
dc.identifier.wosWOS:000327567700004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Neuroimmunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectExperimental autoimmune encephalomyelitisen
dc.subjectExerciseen
dc.subjectBDNFen
dc.subjectNeuroprotectionen
dc.subjectNeuroinflammationen
dc.subjectIntravital microscopyen
dc.titleDifferential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exerciseen
dc.typeinfo:eu-repo/semantics/article
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