The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II

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dc.contributor.authorSchmidt, Thomas J.
dc.contributor.authorKhalid, S. A.
dc.contributor.authorRomanha, Álvaro José
dc.contributor.authorAlves, Tânia Maria de Almeida
dc.contributor.authorBiavatti, Maique Weber
dc.contributor.authorBrun, Reto
dc.contributor.authorCosta, Fernando Batista da
dc.contributor.authorCastro, Solange Lisboa de
dc.contributor.authorFerreira, Vitor Francisco
dc.contributor.authorLacerda, Marcus Vinícius Guimarães de
dc.contributor.authorLago, Joao Henrique Ghilardi [UNIFESP]
dc.contributor.authorLeon, Leonor Laura Pinto
dc.contributor.authorLopes, Norberto Peporine
dc.contributor.authorAmorim, Rodrigo César das Neves
dc.contributor.authorNiehues, Michael
dc.contributor.authorOgungbe, Ifedayo Victor
dc.contributor.authorPohlit, Adrian Martin
dc.contributor.authorScotti, Marcus Tullius
dc.contributor.authorSetzer, William Nathan
dc.contributor.authorSoeiro, Maria de Nazaré Correia
dc.contributor.authorSteindel, Mário
dc.contributor.authorTempone, Andre Gustavo [UNIFESP]
dc.contributor.institutionUniv Munster
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionFiocruz MS
dc.contributor.institutionUniv Basel
dc.contributor.institutionSwiss Trop & Publ Hlth Inst STPH
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFundacao Oswaldo Cruz
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.contributor.institutionFundacao Med Trop Heitor Vieira Dourado
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Nacl de Pesquisas da Amazonia
dc.contributor.institutionUniv Alabama
dc.contributor.institutionUniv Fed Paraiba
dc.contributor.institutionAdolfo Lutz Inst
dc.date.accessioned2018-06-15T17:05:13Z
dc.date.available2018-06-15T17:05:13Z
dc.date.issued2012-05-01
dc.description.abstractInfections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen Neglected Tropical Diseases (NTDs) defined by the WHO. Furthermore, malaria (caused by various Plasmodium species) can be considered a neglected disease in certain countries and with regard to availability and affordability of the antimalarials. Living organisms, especially plants, provide an innumerable number of molecules with potential for the treatment of many serious diseases. The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.In part I, a general description of the diseases, the current state of therapy and need for new therapeuticals, assay methods and strategies applied in the search for new plant derived natural products against these diseases and an overview on natural products of terpenoid origin with antiprotozoal potential were given.The present part II compiles the current knowledge on natural products with antiprotozoal activity that are derived from the shikimate pathway (lignans, coumarins, caffeic acid derivatives), quinones of various structural classes, compounds formed via the polyketide pathways (flavonoids and related compounds, chromenes and related benzopyrans and benzofurans, xanthones, acetogenins from Annonaceae and polyacetylenes) as well as the diverse classes of alkaloids.In total, both parts compile the literature on almost 900 different plant-derived natural products and their activity data, taken from over 800 references. These data, as the result of enormous efforts of numerous research groups world-wide, illustrate that plant secondary metabolites represent an immensely rich source of chemical diversity with an extremely high potential to yield a wealth of lead structures towards new therapies for NTDs. Only a small percentage, however, of the roughly 200,000 plant species on earth have been studied chemically and only a small percentage of these plants or their constituents has been investigated for antiprotozoal activity. The repository of plant-derived natural products hence deserves to be investigated even more intensely than it has been up to present.en
dc.description.affiliationUniv Munster, IPBP, D-48149 Munster, Germany
dc.description.affiliationUniv Fed Santa Catarina, CCB, Dept Microbiol Immunol & Parasitol MIP, Florianopolis, SC, Brazil
dc.description.affiliationFiocruz MS, Ctr Pesquisas Rene Rachou, BR-30190002 Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Santa Catarina, Dept Farm, Florianopolis, SC, Brazil
dc.description.affiliationUniv Basel, CH-4002 Basel, Switzerland
dc.description.affiliationSwiss Trop & Publ Hlth Inst STPH, CH-4002 Basel, Switzerland
dc.description.affiliationUniv Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto FCFRP USP, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationFundacao Oswaldo Cruz, Lab Biol Celular, Inst Oswaldo Cruz, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Fluminense, Inst Quim, Dept Quim Organ, BR-24020150 Niteroi, RJ, Brazil
dc.description.affiliationFundacao Med Trop Heitor Vieira Dourado, BR-69040000 Manaus, Amazonas, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Sao Paulo, Brazil
dc.description.affiliationFundacao Oswaldo Cruz, Lab Bioquim Tripanosomatideos, BR-21040900 Rio De Janeiro, RJ, Brazil
dc.description.affiliationInst Nacl de Pesquisas da Amazonia, BR-69060001 Manaus, Amazonas, Brazil
dc.description.affiliationUniv Alabama, Dept Chem, Huntsville, AL 35899 USA
dc.description.affiliationUniv Fed Paraiba, Dept Enghenaria & Meio Ambiente, Ctr Ciencias Aplicadas & Educ, Rio Tinto, Paraiba, Brazil
dc.description.affiliationAdolfo Lutz Inst, Dept Parasitol, BR-01246902 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipGerman Ministry of Science and Education (BMBF)
dc.format.extent2176-2228
dc.identifierhttps://dx.doi.org/10.2174/092986712800229087
dc.identifier.citationCurrent Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 19, n. 14, p. 2176-2228, 2012.
dc.identifier.doi10.2174/092986712800229087
dc.identifier.issn0929-8673
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/43450
dc.identifier.wosWOS:000303381800006
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectNeglected tropical diseasesen
dc.subjectTrypanosomaen
dc.subjectLeishmaniaen
dc.subjectPlasmodiumen
dc.subjectNatural producten
dc.subjectLignanen
dc.subjectCoumarinen
dc.subjectCaffeic aciden
dc.subjectFlavonoiden
dc.subjectChalconeen
dc.subjectAuroneen
dc.subjectChromeneen
dc.subjectXanthoneen
dc.subjectAcetogeninen
dc.subjectPolyacetyleneen
dc.subjectAlkaloiden
dc.titleThe Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part IIen
dc.typeinfo:eu-repo/semantics/article
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