International Evaluation of MIC Distributions and Epidemiological Cutoff Value (ECV) Definitions for Fusarium Species Identified by Molecular Methods for the CLSI Broth Microdilution Method

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dc.citation.issue2
dc.citation.volume60
dc.contributor.authorEspinel-Ingroff, A.
dc.contributor.authorColombo, Arnaldo Lopes [UNIFESP]
dc.contributor.authorCordoba, S.
dc.contributor.authorDufresne, P. J.
dc.contributor.authorFuller, J.
dc.contributor.authorGhannoum, M.
dc.contributor.authorGonzalez, G. M.
dc.contributor.authorGuarro, J.
dc.contributor.authorKidd, S. E.
dc.contributor.authorMeis, J. F.
dc.contributor.authorMelhem, T. M. S. C.
dc.contributor.authorPelaez, T.
dc.contributor.authorPfaller, M. A.
dc.contributor.authorSzeszs, M. W.
dc.contributor.authorTakahaschi, J. P.
dc.contributor.authorTortorano, A. M.
dc.contributor.authorWiederhold, N. P.
dc.contributor.authorTurnidger, J.
dc.coverageWashington
dc.date.accessioned2020-10-30T18:46:32Z
dc.date.available2020-10-30T18:46:32Z
dc.date.issued2016
dc.description.abstractThe CLSI epidemiological cutoff values (ECVs) of antifungal agents are available for various Candida spp., Aspergillus spp., and the Mucorales. However, those categorical endpoints have not been established for Fusarium spp., mostly due to the difficulties associated with collecting sufficient CLSI MICs for clinical isolates identified according to the currently recommended molecular DNA-PCR-based identification methodologies. CLSI MIC distributions were established for 53 Fusarium dimerum species complex (SC), 10 F. fujikuroi, 82 F. proliferatum, 20 F. incarnatum-F. equiseti SC, 226 F. oxysporum SC, 608 F. solani SC, and 151 F. verticillioides isolates originating in 17 laboratories (in Argentina, Australia, Brazil, Canada, Europe, Mexico, and the United States). According to the CLSI guidelines for ECV setting, ECVs encompassing >= 97.5% of pooled statistically modeled MIC distributions were as follows: for amphotericin B, 4 mu g/ml (F. verticillioides) and 8 mu g/ml (F. oxysporum SC and F. solani SC); for posaconazole, 2 mu g/ml (F. verticillioides), 8 mu g/ml (F. oxysporum SC), and 32 mu g/ml (F. solani SC); for voriconazole, 4 mu g/ml (F. verticillioides), 16 mu g/ml (F. oxysporum SC), and 32 mu g/ml (F. solani SC); and for itraconazole, 32 mu g/ml (F. oxysporum SC and F. solani SC). Insufficient data precluded ECV definition for the other species. Although these ECVs could aid in detecting non-wild-type isolates with reduced susceptibility to the agents evaluated, the relationship between molecular mechanisms of resistance (gene mutations) and MICs still needs to be investigated for Fusarium spp.en
dc.description.affiliationVCU Med Ctr, Richmond, VA 23298 USA
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationInst Nacl Enfermedades Infecciosas Dr CG Malbran, Buenos Aires, DF, Argentina
dc.description.affiliationInst Natl Sante Publ Quebec, Lab Sante Publ Quebec, Ste Anne De Bellevue, PQ, Canada
dc.description.affiliationAlberta Hlth Serv, Prov Lab, Edmonton, AB, Canada
dc.description.affiliationUniv Hosp Case Med Ctr, Cleveland, OH USA
dc.description.affiliationCase Western Reserve Univ, Cleveland, OH 44106 USA
dc.description.affiliationUniv Autonoma Nuevo Leon, Monterrey, Nuevo Leon, Mexico
dc.description.affiliationURV, Fac Med, IISPV, Reus, Spain
dc.description.affiliationSA Pathol, Natl Mycol Reference Ctr, Adelaide, SA, Australia
dc.description.affiliationCanisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
dc.description.affiliationRadboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands
dc.description.affiliationAdolfo Lutz Inst, Reference Ctr, Sao Paulo, Brazil
dc.description.affiliationUniv Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med, E-28040 Madrid, Spain
dc.description.affiliationJMI Labs, North Liberty, IA USA
dc.description.affiliationAdolfo Lutz Inst, Reference Ctr, Dept Mycol, Sao Paulo, Brazil
dc.description.affiliationGrp Fleury, Sao Paulo, Brazil
dc.description.affiliationUniv Milan, Dept Biomed Sci Hlth, Milan, Italy
dc.description.affiliationUniv Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA
dc.description.affiliationUniv Adelaide, Adelaide, SA, Australia
dc.description.affiliationUnifespUniv Fed Sao Paulo, EPM, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1079-1084
dc.identifierhttps://doi.org/10.1128/AAC.02456-15
dc.identifier.citationAntimicrobial Agents And Chemotherapy. Washington, v. 60, n. 2, p. 1079-1084, 2016.
dc.identifier.doi10.1128/AAC.02456-15
dc.identifier.issn0066-4804
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58501
dc.identifier.wosWOS:000369159800041
dc.language.isoeng
dc.publisherAmer Soc Microbiology
dc.relation.ispartofAntimicrobial Agents And Chemotherapy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleInternational Evaluation of MIC Distributions and Epidemiological Cutoff Value (ECV) Definitions for Fusarium Species Identified by Molecular Methods for the CLSI Broth Microdilution Methoden
dc.typeinfo:eu-repo/semantics/article
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