Efficacy and safety of a video-EEG protocol for genetic generalized epilepsies

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dc.citation.volume70
dc.contributor.authorDe Marchi, Luciana Rodrigues [UNIFESP]
dc.contributor.authorCorso, Jeana Torres [UNIFESP]
dc.contributor.authorZetehaku, Ana Carolina [UNIFESP]
dc.contributor.authorPedroso Uchida, Carina Goncalves [UNIFESP]
dc.contributor.authorBittar Guaranha, Mirian Salvadori [UNIFESP]
dc.contributor.authorTargas Yacubian, Elza Marcia [UNIFESP]
dc.coverageSan Diego
dc.date.accessioned2020-07-13T11:53:21Z
dc.date.available2020-07-13T11:53:21Z
dc.date.issued2017
dc.description.abstractIntroduction: Video-EEG has been used to characterize genetic generalized epilepsies (GGE). For best performance, sleep recording, photic stimulation, hyperventilation, and neuropsychological protocols are added to the monitoring. However, risks and benefits of these video-EEG protocols are not well established. The aim of this study was to analyze the efficacy and safety of a video-EEG neuropsychological protocol (VNPP) tailored for GGE and compare its value with that of routine EEG (R-EEG). Methods: We reviewed the VNPP and R-EEG of patients with GGE. We considered confirmation of the clinical suspicion of a GGE syndrome and characterization of reflex traits as benefitsen
dc.description.abstractand falls, injuries, psychiatric and behavioral changes, generalized tonic-clonic (GTC) seizures, and status epilepticus (SE) as the main risks of the VNPP. Results: The VNPPs of 113 patients were analyzed. The most common epileptic syndrome was juvenile myoclonic epilepsy (85.8%). The protocol confirmed a GGE syndrome in 97 patients and 62 had seizures. Sleep recording had a provocative effect in 51.2% of patients. The second task that showed highest efficacy was praxis (39.3%) followed by hyperventilation (313%). Among the risks, 1.8% had GTC seizures and another 1.8%, SE. Eighteen percent of patients had persistently normal R-EEG, 72.2% of them had discharges during VNPP. Generalized tonic-clonic seizures, myoclonic status epilepticus, and repeated seizures were the main risks of VNPP present in 6 (5.31%) patients while there were no complications during R-EEG. Conclusions: The VNPP in GGE is a useful tool in diagnosis and characterization of reflex traits, and is a safe procedure. Its use might preclude multiple R-EEG exams. (C) 2017 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP EPM, Unidade Pesquisa & Tratamento Epilepsias UNIPETE, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP EPM, Unidade Pesquisa & Tratamento Epilepsias UNIPETE, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) from Brazil
dc.description.sponsorshipFundacao Capes from Brazil
dc.description.sponsorshipIDCAPES: 90881
dc.format.extent187-192
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2017.03.029
dc.identifier.citationEpilepsy & Behavior. San Diego, v. 70, p. 187-192, 2017.
dc.identifier.doi10.1016/j.yebeh.2017.03.029
dc.identifier.issn1525-5050
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54561
dc.identifier.wosWOS:000402447700032
dc.language.isoeng
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVideo-EEG neuropsychological protocolen
dc.subjectGenetic generalized epilepsyen
dc.subjectEfficacyen
dc.subjectSafetyen
dc.subjectRoutine EEGen
dc.subjectReflex traitsen
dc.titleEfficacy and safety of a video-EEG protocol for genetic generalized epilepsiesen
dc.typeinfo:eu-repo/semantics/article
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