Risk factors for low bone mineral density in children and adolescents with inflammatory bowel disease

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dc.contributor.authorCaldas Lopes, Leticia Helena [UNIFESP]
dc.contributor.authorSdepanian, Vera Lucia [UNIFESP]
dc.contributor.authorSzejnfeld, Vera Lucia [UNIFESP]
dc.contributor.authorMorais, Mauro Batista de [UNIFESP]
dc.contributor.authorFagundes-Neto, Ulysses [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:44Z
dc.date.available2016-01-24T13:51:44Z
dc.date.issued2008-10-01
dc.description.abstractObjective To evaluate bone mineral density of the lumbar spine in children and adolescents with inflammatory bowel disease, and to identify the clinical risk factors associated with low bone mineral density. Methods Bone mineral density of the lumbar spine was evaluated using dual-energy X-ray absorptiometry (DXA) in 40 patients with inflammatory bowel disease. Patients were 11.8 (SD = 4.1) years old and most of them were male (52.5%). Multiple linear regression analysis was performed to identify potential associations between bone mineral density Z-score and age, height-for-age Z-score, BMI Z-score, cumulative corticosteroid dose in milligrams and in milligrams per kilogram, disease duration, number of relapses, and calcium intake according to the dietary reference intake. Results Low bone mineral density (Z-score bellow -2) was observed in 25% of patients. Patients with Crohn's disease and ulcerative colitis had equivalent prevalence of low bone mineral density. Multiple linear regression models demonstrated that height-for-age Z-score, BMI Z-score, and cumulative corticosteroid dose in mg had independent effects on BMD, respectively, beta = 0.492 (P = 0.000), beta = 0.460 (P = 0.001), beta = -0.014 (P = 0.000), and these effects remained significant after adjustments for disease duration, respectively, beta = 0.489 (P = 0.013), beta = 0.467 (P = 0.001), and beta = -0.005 (P = 0.015). the model accounted for 54.6% of the variability of the BMD Z-score (adjusted R(2) = 0.546). Conclusions the prevalence of low bone mineral density in children and adolescents with inflammatory bowel disease is considerably high and independent risk factors associated with bone mineral density are corticosteroid cumulative dose in milligrams, height-for-age Z-score, and BMI Z-score.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Div Pediat Gastroenterol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Div Rheumatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Div Pediat Gastroenterol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Div Rheumatol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent2746-2753
dc.identifierhttp://dx.doi.org/10.1007/s10620-008-0223-0
dc.identifier.citationDigestive Diseases and Sciences. Dordrecht: Springer, v. 53, n. 10, p. 2746-2753, 2008.
dc.identifier.doi10.1007/s10620-008-0223-0
dc.identifier.issn0163-2116
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30940
dc.identifier.wosWOS:000258833800024
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofDigestive Diseases and Sciences
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectBone mineral densityen
dc.subjectCrohn's diseaseen
dc.subjectcolitisen
dc.subjectulcerativeen
dc.subjectChildrenen
dc.subjectAdolescentsen
dc.subjectmultivariate analysisen
dc.titleRisk factors for low bone mineral density in children and adolescents with inflammatory bowel diseaseen
dc.typeinfo:eu-repo/semantics/article
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