Risk of bacterial infection in patients under intravenous iron therapy: Dose versus length of treatment

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dc.contributor.authorCanziani, MEF
dc.contributor.authorYumiya, S. T.
dc.contributor.authorRangel, E. B.
dc.contributor.authorManfredi, SR
dc.contributor.authorNeto, M. C.
dc.contributor.authorDraibe, S. A.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionOswaldo Ramos Fdn
dc.date.accessioned2016-01-24T12:33:07Z
dc.date.available2016-01-24T12:33:07Z
dc.date.issued2001-11-01
dc.description.abstractSome studies have suggested that intravenous iron therapy may be associated with an increased risk of infection. We analyzed the incidence of bacterial infection in 111 hemodialysis patients. Group 1 (n = 39, transferrin saturation <20%) received 10 doses of 100 mg of intravenous iron saccharate, 3 doses per week (28 treatment days); Group 2 (n = 13, transferrin saturation <20%) received 20 doses, 3 doses per week (70 treatment days); and Group 3 (n = 59, transferrin saturation 20-50%) received 10 doses, 1 dose per week (70 treatment days). the followup was 150 days for all groups, and all infectious episodes were recorded. Pulmonary infection was the most frequent event observed in all of the groups. in an incidence-density analysis, Group 2, which received a total of 20 doses, presented a significantly higher incidence of infection than Group 3, which received only 10 doses over the same period (0.13 versus 0.06 infections per patient per month, p = 0.04). No difference was observed between Groups 1 and 2 suggesting that the risk of infection during iron therapy is dose dependent rather than time length dependent.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.affiliationOswaldo Ramos Fdn, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent866-869
dc.identifierhttp://dx.doi.org/10.1046/j.1525-1594.2001.06894.x
dc.identifier.citationArtificial Organs. Malden: Blackwell Publishing Inc, v. 25, n. 11, p. 866-869, 2001.
dc.identifier.doi10.1046/j.1525-1594.2001.06894.x
dc.identifier.issn0160-564X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26661
dc.identifier.wosWOS:000172801600004
dc.language.isoeng
dc.publisherBlackwell Publishing Inc
dc.relation.ispartofArtificial Organs
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectintravenous ironen
dc.subjectbacterial infectionen
dc.subjecthemodialysisen
dc.titleRisk of bacterial infection in patients under intravenous iron therapy: Dose versus length of treatmenten
dc.typeinfo:eu-repo/semantics/article
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