Effect of APOE and CHRNA7 Genotypes on the Cognitive Response to Cholinesterase Inhibitor Treatment at Different Stages of Alzheimer's Disease

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dc.contributor.authorSampaio Braga, Ianna Lacerda [UNIFESP]
dc.contributor.authorSilva, Patricia Natalia [UNIFESP]
dc.contributor.authorFuruya, Tatiane Katsue [UNIFESP]
dc.contributor.authorSantos, Leonardo Caires [UNIFESP]
dc.contributor.authorPires, Belisa Caldana [UNIFESP]
dc.contributor.authorMazzotti, Diego Robles [UNIFESP]
dc.contributor.authorBertolucci, Paulo Henrique [UNIFESP]
dc.contributor.authorCendoroglo, Maysa Seabra [UNIFESP]
dc.contributor.authorSmith, Marilia Cardoso [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:40:12Z
dc.date.available2016-01-24T14:40:12Z
dc.date.issued2015-03-01
dc.description.abstractThe loss of cholinergic transmission is considered to be an important cause of Alzheimer's disease (AD). Treatment with acetyl cholinesterase inhibitors (ChEIs) shows benefits; however, great heterogeneity has been observed in patient responses. We evaluated apolipoprotein E (APOE) and 7 nicotinic receptor (CHRNA7) single-nucleotide polymorphisms (SNPs) and associated these SNPs with pharmacological responses to ChEIs in a Brazilian population with AD. We studied 177 outpatients using ChEIs, and they were classified as responders and nonresponders according to variation in Mini-Mental State Examination (MMSE) status. the analysis of APOE genotypes showed that patients with the 4 allele had a worse response than those without the 4 allele. We observed an association between the CHRNA7 T allele and a better response to treatment with ChEIs in patients with mild AD (MMSE 20). the SNP rs6494223 of CHRNA7 as well as APOE4 could be useful for understanding the response to ChEI treatment in patients with AD.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Morfol & Genet, Disciplina Genet, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, Disciplina Neurol Clin, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Disciplina Geriatria & Gerontol, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Morfol & Genet, Disciplina Genet, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, Disciplina Neurol Clin, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Disciplina Geriatria & Gerontol, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent139-144
dc.identifierhttp://dx.doi.org/10.1177/1533317514539540
dc.identifier.citationAmerican Journal of Alzheimers Disease and Other Dementias. Thousand Oaks: Sage Publications Inc, v. 30, n. 2, p. 139-144, 2015.
dc.identifier.doi10.1177/1533317514539540
dc.identifier.issn1533-3175
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38863
dc.identifier.wosWOS:000351707000004
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofAmerican Journal of Alzheimers Disease and Other Dementias
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectpharmacogenomicsen
dc.subjectAlzheimer's diseaseen
dc.subjectcholinesterase inhibitoren
dc.subjectCHRNA7en
dc.subjectAPOEen
dc.titleEffect of APOE and CHRNA7 Genotypes on the Cognitive Response to Cholinesterase Inhibitor Treatment at Different Stages of Alzheimer's Diseaseen
dc.typeinfo:eu-repo/semantics/article
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