Central and peripheral effects of physical exercise without weight reduction in obese and lean mice

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dc.citation.volumev. 38
dc.contributor.authorCarvalho, Francine Pereira de [UNIFESP]
dc.contributor.authorMoretto, Thais Ludmilla [UNIFESP]
dc.contributor.authorBenfato, Izabelle Dias [UNIFESP]
dc.contributor.authorBarthichoto, Marcela [UNIFESP]
dc.contributor.authorFerreira, Sandra Mara
dc.contributor.authorCosta-Junior, Jose Maria
dc.contributor.authorOliveira, Camila Aparecida Machado de [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-20T16:30:59Z
dc.date.available2020-07-20T16:30:59Z
dc.date.issued2018
dc.description.abstractTo investigate the central (hypothalamic) and peripheral effects of exercise without body weight change in diet-induced obesity (DIO). Twelve-week-old male C57Bl/6 mice received a control (C) or a high-fat diet (H). Half of them had free access to running wheels for 5 days/week for 10 weeks (CE) and HE, respectively). Hypothalamic expression of genes related to energy homeostasis, and leptin (Stat3 and p-Stat3) and insulin (Akt and p-Akt) signaling were evaluated. Glucose and leptin tolerance, peripheral insulin sensitivity, and plasma insulin, leptin and adiponectin were determined. Perigonadal and retroperitoneal fat depots were increased by diet but reduced by exercise despite lack of effect of exercise on body weight. Blood glucose during intraperitoneal glucose tolerance test (ipGTT) was higher and glucose decay during intraperitoneal insulin tolerance test (ipITT) was lower in H and HE compared with C and CE. Exercise increased liver p-Akt expression and reduced fast glycemia. High-fat diet increased plasma insulin and leptin. Exercise had no effect on insulin but decreased leptin and increased adiponectin. Leptin inhibited food intake in all groups. Hypothalamic total and p-Stat3 and Akt were similar amongst the groups despite higher plasma levels of leptin and insulin in H and HE mice. High-fat diet modulated gene expression favoring a positive energy balance. Exercise only marginally changed the gene expression. Exercise induced positive changes (decreased fast glycemia and fat depots; increased liver insulin signaling and adiponectin concentration) without weight loss. Thus, despite reducing body weight could bring additional benefits, the effects of exercise must not be overlooked when weight reduction is not achieved.en
dc.description.affiliationUniv Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Programa Posgrad Alimentos Nutr & Saude, Santos, SP, Brazil
dc.description.affiliationUniv Estadual Campinas Unicamp, Inst Biol, Dept Biol Func & Estrutural, Campinas, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Saude & Soc, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Programa Posgrad Alimentos Nutr & Saude, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Saude & Soc, Dept Biociencias, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2011/05932-3
dc.description.sponsorshipIDFAPESP: 2013/01624-8
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1042/BSR20171033
dc.identifier.citationBioscience Reports. London, v. 38, p. -, 2018.
dc.identifier.doi10.1042/BSR20171033
dc.identifier.fileWOS000431504200007.pdf
dc.identifier.issn0144-8463
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55624
dc.identifier.wosWOS:000431504200007
dc.language.isoeng
dc.publisherPortland Press Ltd
dc.relation.ispartofBioscience Reports
dc.rightsAcesso aberto
dc.titleCentral and peripheral effects of physical exercise without weight reduction in obese and lean miceen
dc.typeArtigo
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