Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile

dc.contributor.authorSilva, Narjara Pereira da
dc.contributor.authorSuano de Souza, Fabiola Isabel
dc.contributor.authorPendezza, Aline Ifanger
dc.contributor.authorAffonso Fonseca, Fernando Luiz
dc.contributor.authorHix, Sonia
dc.contributor.authorOliveira, Allan Chiaratti [UNIFESP]
dc.contributor.authorSarni, Roseli Oselka Saccardo [UNIFESP]
dc.contributor.authorD'Almeida, Vania [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFac Med ABC
dc.description.abstractObjective: To evaluate homocysteine and total cysteine levels in prepubertal children and to determine the association between these levels and obesity, increased waist circumference, glucose levels, and lipid profile alterations.Methods: Using a cross-sectional study, 677 prepubertal students 6 to 11 y old were assessed. the weight, height, and waist circumference of the students were measured. Laboratory analyses included triacylglycerols, total cholesterol and its fractions, glucose, vitamin B12, folate, homocysteine, and cysteine. Chi-square tests and logistic regression (forward-stepwise) were used for statistical analysis; the significance level was set at 5%.Results: the median age of the students was 8.9 y (6.5-11.5), and the prevalences of overweight and obesity were 90 in 677 (13.3%) and 81 in 677 (12.0%). respectively. An increase in waist circumference was observed in 180 of 677 children (26.6%). Inadequate levels of low-density lipoprotein cholesterol, triacylglycerols, and high-density lipoprotein cholesterol were found in 95 (14.0%), 129 (19.1%), and 179 (26.4%) of the 677 students, respectively. the median homocysteine and total cysteine plasma levels were 5.6 mu mol/L (0.1-11.7) and 365.7 mu mol/L (191.5-589.2), respectively. A multivariate analysis showed that children with a waist circumference above the 90th percentile (7.3 mu mol/L) were 2.4 times (95% confidence interval 1.4-4.0) more likely to have increased homocysteine levels and that children with increased waist circumferences and those with high low-density lipoprotein cholesterol levels were 2.7 (95% confidence interval 1.6-4.6) and 2.1 (95% confidence interval 1.1-4.0) times more likely, respectively, to have total cysteine levels above the 90th percentile (445.0 mu mol/L).Conclusion: the association of abdominal obesity in prepuberty with levels of homocysteine and cysteine found in this study of a prepubertal population could be an early and independent predictor of cardiovascular risk. (C) 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationFac Med ABC, Dept Pediat, São Paulo, Brazil
dc.description.affiliationFac Med ABC, Curso Ciencias Farmaceut, São Paulo, Brazil
dc.description.affiliationFac Med ABC, Disciplina Bioquim, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Lab Erros Inatos Metab, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Lab Erros Inatos Metab, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.identifier.citationNutrition. New York: Elsevier B.V., v. 29, n. 1, p. 166-171, 2013.
dc.publisherElsevier B.V.
dc.rightsAcesso aberto
dc.subjectWaist circumferenceen
dc.titleHomocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profileen