Grape Juice Concentrate Protects Rat Liver Against Cadmium Intoxication: Histopathology, Cytochrome C and Metalloproteinases Expression

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dc.citation.issue7
dc.citation.volume66
dc.contributor.authorMoura, Carolina Foot Gomes de [UNIFESP]
dc.contributor.authorRibeiro, Flavia Andressa Pidone [UNIFESP]
dc.contributor.authorHandan, Bianca Andrade [UNIFESP]
dc.contributor.authorAguiar, Odair [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.coverageStuttgart
dc.date.accessioned2020-08-14T13:44:27Z
dc.date.available2020-08-14T13:44:27Z
dc.date.issued2016
dc.description.abstractThe aim of this study was to investigate if grape juice concentrate is able to protect rat liver against cadmium toxicity. For this purpose, histopathological analysis, cytochrome C expression and immunoexpresssion of metalloproteinases (MMP) 2 and 9 were investigated. A total of 15 Wistar rats weighing 250 g on the average, and 8 weeks age were distributed into 3 groups (n = 5), as follows: Control group (non-treated group, CTRL)en
dc.description.abstractCadmium group (Cd) and grape juice concentrate group (Cd + GJ). Histopathological analysis revealed that liver from animals treated with grape juice concentrate improved tissue degeneration induced by cadmium intoxication. Animals intoxicated with cadmium and treated with grape juice concentrate showed higher cytochrome C gene expression in liver cells. No significant statistically differences (p > 0.05) were found to MMP 2 and 9 immuno-expression between groups. Taken together, our results demonstrate that grape juice concentrate is able to prevent tissue degeneration in rat liver as a result of increasing apoptosis.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biociencias, UNIFESP, Ave Ana Costa 95, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pathol, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biociencias, UNIFESP, Ave Ana Costa 95, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pathol, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.format.extent339-344
dc.identifierhttps://dx.doi.org/10.1055/s-0035-1569452
dc.identifier.citationDrug Research. Stuttgart, v. 66, n. 7, p. 339-344, 2016.
dc.identifier.doi10.1055/s-0035-1569452
dc.identifier.issn2194-9379
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57673
dc.identifier.wosWOS:000379389100002
dc.language.isoeng
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofDrug Research
dc.rightsAcesso restrito
dc.subjectGrape juice concentrateen
dc.subjectCadmiumen
dc.subjectRaten
dc.subjectCytochrome Cen
dc.subjectMetalloproteinasesen
dc.titleGrape Juice Concentrate Protects Rat Liver Against Cadmium Intoxication: Histopathology, Cytochrome C and Metalloproteinases Expressionen
dc.typeArtigo
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