Tamoxifen use for the management of mania: a review of current preclinical evidence

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dc.contributor.authorArmani, Fernanda [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorFernandes Galduroz, Jose Carlos [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:35:12Z
dc.date.available2016-01-24T14:35:12Z
dc.date.issued2014-02-01
dc.description.abstractPreliminary data on the efficacy of tamoxifen in reducing manic symptoms of bipolar disorder (BD) suggest that this agent may be a potential treatment for the management of this psychiatric disorder. However, the antimanic properties of tamoxifen have not been fully elucidated, hampering the development and/or use of mood-stabilising drugs that may share its same therapeutic mechanisms of action. Notably, we may gain a greater understanding of the neurobiological and therapeutic properties of tamoxifen by using suitable animal models of mania.Here, we review the preclinical studies that have evaluated the effects of tamoxifen to provide an overview of the current progress in our understanding of its antimanic actions, highlighting the critical role of protein kinase C (PKC) as a therapeutic target for the treatment of BD.To date, this field has struggled to make significant progress, and the organisation of an explicit battery of tests is a valuable tool for assessing a number of prominent facets of BD, which may provide a greater understanding of the entire scope of this disease.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent639-649
dc.identifierhttp://dx.doi.org/10.1007/s00213-013-3397-x
dc.identifier.citationPsychopharmacology. New York: Springer, v. 231, n. 4, p. 639-649, 2014.
dc.identifier.doi10.1007/s00213-013-3397-x
dc.identifier.issn0033-3158
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37357
dc.identifier.wosWOS:000330983500002
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofPsychopharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectBipolar disorderen
dc.subjectManiaen
dc.subjectTamoxifenen
dc.subjectProtein kinase C (PKC)en
dc.subjectAnimal modelsen
dc.subjectAntimanic treatmenten
dc.titleTamoxifen use for the management of mania: a review of current preclinical evidenceen
dc.typeinfo:eu-repo/semantics/article
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