Is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysis

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dc.citation.issue2
dc.citation.volume13
dc.contributor.authorYazbek, Daniel Constantino [UNIFESP]
dc.contributor.authorCarvalho, Aluizio Barbosa [UNIFESP]
dc.contributor.authorBarros, Cinara Sa [UNIFESP]
dc.contributor.authorMedina Pestana, Jose Osmar [UNIFESP]
dc.contributor.authorRochitte, Carlos Eduardo
dc.contributor.authordos Santos Filho, Raul Dias
dc.contributor.authorCanziani, Maria Eugenia F. [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-07-08T13:09:39Z
dc.date.available2020-07-08T13:09:39Z
dc.date.issued2018
dc.description.abstractBackground Epicardial fat (EF) has been related to increased cardiovascular risk in chronic kidney disease patients. Kidney transplantation is associated with weight gain, especially within the first 12 months. Recently an association between EF and left ventricular mass (LVM) has been suggested in kidney transplant (KTX) recipients. Objective Evaluate the EF in KTX recipients and its association with cardiovascular parameters in a 12-month follow-up study. Methods EF volume was determined using thoracic computed tomography. The EF progressor group (EF gain) was defined by any increment in EF after 12 months. LVM and LVM index were calculated by echocardiography. Results Ninety-eight incident KTX patients [57% men, 41.2 +/- 10.1 years, mean dialysis time prior to transplant of 24 (11 +/- 60) months] were analyzed. At baseline and after 12 months, EF was 318.6 (275.2 +/- 392.6) ml and 329.5 (271.7 +/- 384.8) ml, respectively (p = 0.03). When compared to patients who EF decreased (n = 33), those with EF gain (n = 65) had a greater increase of body mass index, abdominal circumference and blood glucose. These patients also had a lower reduction of LVM index. However in the multivariate analysis, there was no difference in LVM index change between groups (interaction p = 0.565), even after adjustment for hypertension, glucose and coronary calcium score (interaction p = 0.538). Conclusion The impact of EF gain on ventricular mass after KTX could not be definitely confirmed. Further prospective studies in a large sample of KTX patients should be considered to address a possible causal relationship between EF gain and cardiac hypertrophy in this population.en
dc.description.affiliationUniv Fed Sao Paulo, Div Nephrol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Heart Inst InCor, Cardiovasc Magnet Resonance & Computed Tomog Sect, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Heart Inst InCor, Lipid Clin, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Nephrol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0191009
dc.identifier.citationPlos One. San Francisco, v. 13, n. 2, p. -, 2018.
dc.identifier.doi10.1371/journal.pone.0191009
dc.identifier.fileWOS000425604300006.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54116
dc.identifier.wosWOS:000425604300006
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleIs there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysisen
dc.typeinfo:eu-repo/semantics/article
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