Acute exhaustive exercise regulates IL-2, IL-4 and MyoD in skeletal muscle but not adipose tissue in rats

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dc.contributor.authorRosa Neto, José Cesar [UNIFESP]
dc.contributor.authorLira, Fabio Santos de [UNIFESP]
dc.contributor.authorZanchi, Nelo E.
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorPimentel, Gustavo Duarte [UNIFESP]
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.contributor.authorSeelaender, Marilia
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:16:53Z
dc.date.available2016-01-24T14:16:53Z
dc.date.issued2011-06-13
dc.description.abstractBackground: the purpose of this study was to evaluate the effect of exhaustive exercise on proteins associated with muscle damage and regeneration, including IL-2, IL-4 and MyoD, in extensor digitorum longus (EDL) and soleus muscles and mesenteric (MEAT) and retroperitoneal adipose tissues (RPAT).Methods: Rats were killed by decapitation immediately (E0 group, n = 6), 2 (E2 group, n = 6) or 6 (E6 group, n = 6) hours after the exhaustion protocol, which consisted of running on a treadmill at approximately 70% of VO(2max) for fifty minutes and then at an elevated rate that increased at one m/min every minute, until exhaustion.Results: the control group (C group, n = 6) was not subjected to exercise. IL-2 protein expression increased at E0 in the soleus and EDL; at E2, this cytokine returned to control levels in both tissues. in the soleus, IL-2 protein expression was lower than that in the control at E6. IL-4 protein levels increased in EDL at E6, but the opposite result was observed in the soleus. MyoD expression increased at E6 in EDL.Conclusion: Exhaustive exercise was unable to modify IL-2 and IL-4 levels in MEAT and RPAT. the results show that exhaustive exercise has different effects depending on which muscle is analysed.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol Nutr, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Phys Educ & Sports, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci 1, Dept Cell Biol & Dev, Mol Cell Biol Study Grp, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol Nutr, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent6
dc.identifierhttps://dx.doi.org/10.1186/1476-511X-10-97
dc.identifier.citationLipids in Health and Disease. London: Biomed Central Ltd, v. 10, 6 p., 2011.
dc.identifier.doi10.1186/1476-511X-10-97
dc.identifier.fileWOS000292812900001.pdf
dc.identifier.issn1476-511X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/33799
dc.identifier.wosWOS:000292812900001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofLipids in Health and Disease
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleAcute exhaustive exercise regulates IL-2, IL-4 and MyoD in skeletal muscle but not adipose tissue in ratsen
dc.typeinfo:eu-repo/semantics/article
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