Determinants of quality of life in advanced cancer patients with bone metastases undergoing palliative radiation treatment

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dc.contributor.authorLam, Kinsey
dc.contributor.authorChow, Edward
dc.contributor.authorZhang, Liying
dc.contributor.authorWong, Erin
dc.contributor.authorBedard, Gillian
dc.contributor.authorFairchild, Alysa
dc.contributor.authorVassiliou, Vassilios
dc.contributor.authorEl-Din, Mohamed Alm
dc.contributor.authorJesus-Garcia, Reynaldo [UNIFESP]
dc.contributor.authorKumar, Aswin
dc.contributor.authorForges, Fabien
dc.contributor.authorTseng, Ling-Ming
dc.contributor.authorHou, Ming-Feng
dc.contributor.authorChie, Wei-Chu
dc.contributor.authorBottomley, Andrew
dc.contributor.institutionUniv Toronto
dc.contributor.institutionUniv Alberta
dc.contributor.institutionBank Cyprus Oncol Ctr
dc.contributor.institutionTanta Univ Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionReg Canc Ctr
dc.contributor.institutionSt Etienne Univ Hosp
dc.contributor.institutionNatl Yang Ming Univ
dc.contributor.institutionKaohsiung Med Univ Hosp
dc.contributor.institutionNatl Taiwan Univ
dc.contributor.institutionEuropean Org Res Treatment Canc
dc.date.accessioned2016-01-24T14:34:39Z
dc.date.available2016-01-24T14:34:39Z
dc.date.issued2013-11-01
dc.description.abstractAssessment of health-related quality of life (HRQOL) is critical to effective delivery of palliative care in patients with advanced cancer. the current study analyzes relationships between baseline social determinants of health and medical factors, and self-reported HRQOL in patients with bone metastases receiving palliative radiotherapy.Advanced cancer patients referred for radiotherapy treatment of bone metastases completed the EORTC QLQ-C30 questionnaire in multiple outpatient clinics internationally. Demographics and social determinants were collected as baseline information. Univariate and Bonferroni-adjusted multivariate linear regression analyses were used to detect significant correlations between baseline determinants and different HRQOL domains.Karnofsky Performance Status (KPS) was correlated with better physical (p = 0.0002), role (p < 0.0001), emotional (p < 0.0001), and social (p < 0.0001) functioning, and global health scores (p = 0.0015) and predicted lower symptom scores for fatigue (p < 0.0001), pain (p < 0.0001), appetite loss (p < 0.0001), and constipation (p < 0.0001). Increased age was predictive of better social functioning (p < 0.0001) and less insomnia (p = 0.0036), higher education correlated with better global health status (p = 0.0043), and patients who were employed or retired had improved physical functioning (p = 0.0004 and p = 0.0030, respectively) and less financial challenges compared to patients who were unemployed (p = 0.0005).Baseline KPS had the greatest influence on EORTC QLQ-C30 domain scores. Age, education level, and employment status had significant impacts, although on fewer domains. Further studies that investigate baseline determinants are worthwhile to clarify relationships in order to care for patients more effectively at the end of life.en
dc.description.affiliationUniv Toronto, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Odette Canc Ctr, Toronto, ON M4N 3M5, Canada
dc.description.affiliationUniv Alberta, Dept Radiat Oncol, Cross Canc Inst, Edmonton, AB, Canada
dc.description.affiliationBank Cyprus Oncol Ctr, Dept Radiat Oncol, Nicosia, Cyprus
dc.description.affiliationTanta Univ Hosp, Dept Clin Oncol, Tanta Fac Med, Tanta, Egypt
dc.description.affiliationUniversidade Federal de São Paulo, Dept Orthoped Oncol, São Paulo, Brazil
dc.description.affiliationReg Canc Ctr, Div Gynaecol & Genitourinary Oncol, Dept Radiat Oncol, Trivandrum 695011, Kerala, India
dc.description.affiliationSt Etienne Univ Hosp, Inserm CIE3, St Etienne, France
dc.description.affiliationSt Etienne Univ Hosp, Unit Clin Res Innovat & Pharmacol, St Etienne, France
dc.description.affiliationNatl Yang Ming Univ, Dept Surg, Taipei Vet Gen Hosp, Taipei 112, Taiwan
dc.description.affiliationKaohsiung Med Univ Hosp, Dept Surg Gastroenterol, Kaohsiung, Taiwan
dc.description.affiliationNatl Taiwan Univ, Dept Publ Hlth, Taipei 10764, Taiwan
dc.description.affiliationNatl Taiwan Univ, Inst Epidemiol & Preventat Med, Taipei 10764, Taiwan
dc.description.affiliationEuropean Org Res Treatment Canc, EORTC Headquarters, Brussels, Belgium
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Orthoped Oncol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBratty Family Fund
dc.description.sponsorshipMichael and Karyn Goldstein Cancer Research Fund
dc.description.sponsorshipJoseph and Silvana Melara Cancer Research Fund
dc.description.sponsorshipOfelia Cancer Research Fund
dc.format.extent3021-3030
dc.identifierhttp://dx.doi.org/10.1007/s00520-013-1876-6
dc.identifier.citationSupportive Care in Cancer. New York: Springer, v. 21, n. 11, p. 3021-3030, 2013.
dc.identifier.doi10.1007/s00520-013-1876-6
dc.identifier.issn0941-4355
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36929
dc.identifier.wosWOS:000325390600011
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofSupportive Care in Cancer
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectQuality of lifeen
dc.subjectSocial determinantsen
dc.subjectBaseline factorsen
dc.subjectEORTC QLQ-C30en
dc.subjectBone metastasesen
dc.subjectAdvanced canceren
dc.titleDeterminants of quality of life in advanced cancer patients with bone metastases undergoing palliative radiation treatmenten
dc.typeinfo:eu-repo/semantics/article
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