Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women

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dc.contributor.authorCorrêa, Silvana Aparecida Alves [UNIFESP]
dc.contributor.authorNoronha, Samuel Marcos Ribeiro de [UNIFESP]
dc.contributor.authorNogueira-de-Souza, Naiara Corrêa [UNIFESP]
dc.contributor.authorCarvalho, Cristina Valletta de [UNIFESP]
dc.contributor.authorCosta, Ana Maria Massad [UNIFESP]
dc.contributor.authorLinhares, Jose Juvenal [UNIFESP]
dc.contributor.authorGomes, Mariano Tamura Vieira [UNIFESP]
dc.contributor.authorSilva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:18Z
dc.date.available2016-01-24T13:52:18Z
dc.date.issued2009-03-01
dc.description.abstractIntroduction. We evaluated the assocation between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type I (AT(1))-receptor A1166C polymorphisms.Methods. Genotyping was performed by PCR-RFLP (restriction fragment length polymorphism) or PCR (polymerase chain reaction) using genomic DNA extracted from buccal cells of subjects with (101 cases) or without (307 controls) breast cancer.Results. the frequencies of genotypes for ACE were: DD, ID and II (in %: cases: 60; 20; 20; controls: 46; 37; 17; p=0.019, chi(2) ); and for AT(1)-receptor were: AA, AC and CC (in %; cases: 65; 30; 5; controls: 51; 44; 5; p=0.114, chi(2)). the results suggested that the A1166C polymorphism was not associated with breast cancer risk. On the other hand, for the ACE (I/D), there seemed to be different risks for cancer between cases and controls.Conclusions. the ID genotype was less frequently associated with the disease than were the DD or II; that is, women with the ID genotype were 3.1 times less likely to develop breast cancer than those with the other genotypes. the ID genotype might be protective against breast cancer and the ACE (I/D) polymorphism a possible targer for developing genetic markers for breast cancer.en
dc.description.affiliationUniversidade Federal de São Paulo, Mol Gynaecol Lab, Dept Gynaecol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Mol Gynaecol Lab, Dept Gynaecol, BR-04039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent51-58
dc.identifierhttps://dx.doi.org/10.1177/1470320309102317
dc.identifier.citationJournal of the Renin-angiotensin-aldosterone System. London: Sage Publications Ltd, v. 10, n. 1, p. 51-58, 2009.
dc.identifier.doi10.1177/1470320309102317
dc.identifier.issn1470-3203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/31337
dc.identifier.wosWOS:000265789800008
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal of the Renin-angiotensin-aldosterone System
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectAngiotensin-converting enzymeen
dc.subjectAngiotensin II type 1 receptoren
dc.subjectBreast canceren
dc.subjectGenotypingen
dc.subjectPolymorphismsen
dc.titleAssociation between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian womenen
dc.typeinfo:eu-repo/semantics/article
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