Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus

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dc.citation.issue4
dc.citation.volume59
dc.contributor.authorGoncalves, Sarah Santos [UNIFESP]
dc.contributor.authorRemondi Souza, Ana Carolina [UNIFESP]
dc.contributor.authorChowdhary, Anuradha
dc.contributor.authorMeis, Jacques F.
dc.contributor.authorColombo, Arnaldo Lopes [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-08-21T16:59:39Z
dc.date.available2020-08-21T16:59:39Z
dc.date.issued2016
dc.description.abstractThe significant increase in the use of antifungal agents, both for the treatment of candidiasis and invasive aspergillosis and as azole fungicides in agricultural crop protection has resulted in the emergence of resistant clinical isolates, particularly to triazoles and echinocandins. Notably, among isolates that were primarily sensitive to fluconazole such as Candida parapsilosis and Candida tropicalis have witnessed an emerging resistance development. Also for echinocandins, the occurrence of Candida isolates with lower susceptibility to these drugs has been reported, which is possibly due to its broad clinical use. Triazole resistance among Aspergillus fumigatus and other Aspergillus species is commonly found in European and Asian countries. Specific mutations are associated with azole resistance in A. fumigatus and these mutations are now reported globally from six continents. Therefore, we highlight the need to conduct antifungal resistance surveillance studies using clinical isolates of Candida and Aspergillus in different geographical regions and monitoring of the infection rates in distinct population groups for early detection of resistance to these drugs and implementation of efficient policies for infection control and treatment.en
dc.description.affiliationUniv Fed Sao Paulo, Lab Especial Micol, Disciplina Infectol, Escola Paulista Med, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Delhi, Vallabhbhai Patel Chest Inst, Dept Med Mycol, Delhi 110007, India
dc.description.affiliationCanisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
dc.description.affiliationRadboud Univ Nijmegen, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands
dc.description.affiliationUnifespUniv Fed Sao Paulo, Lab Especial Micol, Disciplina Infectol, Escola Paulista Med, BR-04039032 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil
dc.description.sponsorshipIDFAPESP: 2012/04767-1
dc.description.sponsorshipIDFAPESP: 2012/04769-4
dc.description.sponsorshipIDCNPq: 308011/2010-4
dc.description.sponsorshipIDCAPES: PNPD 23038.007393/2011-11
dc.description.sponsorshipIDFAPESP : 2012/04769-4
dc.format.extent198-219
dc.identifierhttp://dx.doi.org/10.1111/myc.12469
dc.identifier.citationMycoses. Hoboken, v. 59, n. 4, p. 198-219, 2016.
dc.identifier.doi10.1111/myc.12469
dc.identifier.fileWOS000372295900001.pdf
dc.identifier.issn0933-7407
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57733
dc.identifier.wosWOS:000372295900001
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMycoses
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntifungal resistanceen
dc.subjectCandida sppen
dc.subjectAspergillus sppen
dc.subjectazolesen
dc.subjectechinocandinsen
dc.subjectamphotericin Ben
dc.titleEpidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillusen
dc.typeinfo:eu-repo/semantics/article
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