Humoral and Cellular Immune Responses to Measles and Tetanus: the Importance of Elapsed Time Since Last Exposure and the Nature of the Antigen

Página do item simplificado
dc.contributor.authorViana, Patricia O. [UNIFESP]
dc.contributor.authorOno, Erika [UNIFESP]
dc.contributor.authorMiyamoto, Maristela [UNIFESP]
dc.contributor.authorSalomao, Reinaldo [UNIFESP]
dc.contributor.authorCosta-Carvalho, Beatriz T. [UNIFESP]
dc.contributor.authorWeckx, Lily Y. [UNIFESP]
dc.contributor.authorMoraes-Pinto, Maria Isabel de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:07Z
dc.date.available2016-01-24T14:05:07Z
dc.date.issued2010-07-01
dc.description.abstractThis study aims to assess the cellular and humoral immune response pre- and post-vaccine rechallenge in healthy adults with previous exposure to measles (virus or vaccine) and different time intervals since last tetanus vaccine.Humoral immunity was tested by ELISA, and cellular immunity was tested by intracellular interferon gamma detection after in vitro stimulation with antigens.While cellular immunity was comparable among vaccinated individuals and those who had measles, higher antibody levels were found in those who had the disease in the past. Both antibodies and CD4(+) T cell tetanus immune responses depended on elapsed time since last immunization. Following a vaccine booster, an increase in cellular immunity and antibodies was observed to both tetanus and measles. Measles humoral response was much more intense among individuals previously exposed to a wild virus.In an era when natural boosters are less frequent, an immune surveillance might be necessary to investigate waning immunity as occurs for tetanus.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pediat, Div Pediat Infect Dis, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Infect Dis, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pediat, Div Allergy & Clin Immunol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pediat, Div Pediat Infect Dis, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Infect Dis, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pediat, Div Allergy & Clin Immunol, BR-04039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 05/57802-5
dc.description.sponsorshipIDFAPESP: 05/57571-3
dc.format.extent574-582
dc.identifierhttp://dx.doi.org/10.1007/s10875-010-9420-7
dc.identifier.citationJournal of Clinical Immunology. New York: Springer/plenum Publishers, v. 30, n. 4, p. 574-582, 2010.
dc.identifier.doi10.1007/s10875-010-9420-7
dc.identifier.issn0271-9142
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32671
dc.identifier.wosWOS:000279683900013
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Clinical Immunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectMeaslesen
dc.subjecttetanusen
dc.subjectcellular immunityen
dc.subjectantibodyen
dc.subjectimmunologic memoryen
dc.titleHumoral and Cellular Immune Responses to Measles and Tetanus: the Importance of Elapsed Time Since Last Exposure and the Nature of the Antigenen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos