A peptidorhamnomannan from the mycelium of Pseudallescheria boydii is a potential diagnostic antigen of this emerging human pathogen

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dc.contributor.authorPinto, Marcia R.
dc.contributor.authorMulloy, Barbara
dc.contributor.authorHaido, Rosa Maria Tavares
dc.contributor.authorTravassos, Luiz Rodolpho [UNIFESP]
dc.contributor.authorBarreto-Bergter, Eliana
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionNatl Inst Biol Stand & Controls
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:04:05Z
dc.date.available2018-06-18T11:04:05Z
dc.date.issued2001-06-01
dc.description.abstractThe ascomycete Pseudallescheria boydii is an emerging human pathogen frequently found in soil and polluted water. A peptidopolysaccharide antigen has been isolated from mycelial forms of P, boydii. and characterized using chemical and immunological methods. Monosaccharide composition, methylation analysis, and H-1- and C-13-NMR spectra indicated the presence of a rhamnomannan with a structure distinct from those of similar components isolated from other fungi, containing Rhap(1 --> 3)Rhap epitopes on side chains which may be linked (1 --> 3) to (1 --> 6)-linked mannose, The peptido-rhamnomannan from P. boydii reacted poorly with an antiserum raised against whole cells of Sporothrix schenckii and strongly with one against P. boydii hyphae, These characteristics and immunological differences suggest that this major rhamnose-containing antigen of P, boydii may be useful for the specific diagnosis of infections attributable to this fungus.en
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Microbiol, CCS, BR-21941970 Rio De Janeiro, Brazil
dc.description.affiliationNatl Inst Biol Stand & Controls, Potters Bar EN6 3QG, Herts, England
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Biomed, Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Disciplina Biol Celular, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Disciplina Biol Celular, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1499-1506
dc.identifierhttp://dx.doi.org/10.1099/00221287-147-6-1499
dc.identifier.citationMicrobiology-sgm. Reading: Soc General Microbiology, v. 147, n. 6, p. 1499-1506, 2001.
dc.identifier.doi10.1099/00221287-147-6-1499
dc.identifier.issn1350-0872
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44905
dc.identifier.wosWOS:000169194100012
dc.language.isoeng
dc.publisherSoc General Microbiology
dc.relation.ispartofMicrobiology-sgm
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfungal pathogenen
dc.subjectmyceliumen
dc.subjectpeptidopolysaccharideen
dc.subjectH-1- and C-13-nuclear magnetic resonanceen
dc.titleA peptidorhamnomannan from the mycelium of Pseudallescheria boydii is a potential diagnostic antigen of this emerging human pathogenen
dc.typeinfo:eu-repo/semantics/article
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