Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors

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dc.contributor.authorZhou, Pengcheng
dc.contributor.authorPorcionatto, Marimélia Aparecida [UNIFESP]
dc.contributor.authorPilapil, Mariecel
dc.contributor.authorChen, Yicheng
dc.contributor.authorChoi, Yoojin
dc.contributor.authorTolias, Kimberley F.
dc.contributor.authorBikoff, Jay B.
dc.contributor.authorHong, Elizabeth J.
dc.contributor.authorGreenberg, Michael E.
dc.contributor.authorSegal, Rosalind A.
dc.contributor.institutionDana Farber Canc Inst
dc.contributor.institutionHarvard Univ
dc.contributor.institutionChildrens Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionBaylor Coll Med
dc.date.accessioned2016-01-24T13:48:52Z
dc.date.available2016-01-24T13:48:52Z
dc.date.issued2007-07-05
dc.description.abstractDuring development, neural precursors migrate in response to positional cues such as growth factor gradients. However, the mechanisms that enable precursors to sense and respond to such gradients are poorly understood. Here we show that cerebellar granule cell precursors (GCPs) migrate along a gradient of brain-derived neurotrophic factor (BDNF), and we demonstrate that vesicle trafficking is critical for this chemotactic process. Activation of TrkB, the BDNF receptor, stimulates GCPs to secrete BDNF, thereby amplifying the ambient gradient. the BDNF gradient stimulates endocytosis of TrkB and associated signaling molecules, causing asymmetric accumulation of signaling endosomes at the subcellular location where BDNF concentration is maximal. Thus, regulated BDNF exocytosis; and TrkB endocytosis enable precursors to polarize and migrate in a directed fashion along a shallow BDNF gradient.en
dc.description.affiliationDana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
dc.description.affiliationHarvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
dc.description.affiliationChildrens Hosp, Div Neurosci, Boston, MA 02115 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biochem, São Paulo, Brazil
dc.description.affiliationBaylor Coll Med, Dept Neurosci, Houston, TX 77030 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biochem, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent53-68
dc.identifierhttp://dx.doi.org/10.1016/j.neuron.2007.05.030
dc.identifier.citationNeuron. Cambridge: Cell Press, v. 55, n. 1, p. 53-68, 2007.
dc.identifier.doi10.1016/j.neuron.2007.05.030
dc.identifier.fileWOS000248010700008.pdf
dc.identifier.issn0896-6273
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29872
dc.identifier.wosWOS:000248010700008
dc.language.isoeng
dc.publisherCell Press
dc.relation.ispartofNeuron
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePolarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursorsen
dc.typeinfo:eu-repo/semantics/article
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