Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice

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dc.contributor.authorBella, Leonardo M.
dc.contributor.authorFieri, Isis
dc.contributor.authorTessaro, Fernando H. G.
dc.contributor.authorNolasco, Eduardo L.
dc.contributor.authorNunes, Fernanda P. B.
dc.contributor.authorFerreira, Sabrina S.
dc.contributor.authorAzevedo, Carolina B. [UNIFESP]
dc.contributor.authorMartins, Joilson O.
dc.coverageLondon
dc.date.accessioned2020-07-31T12:46:42Z
dc.date.available2020-07-31T12:46:42Z
dc.date.issued2017
dc.description.abstractBackground/Aims. The effects of cholecalciferol supplementation on the course of diabetes in humans and animals need to be better understood. Therefore, this study investigated the effect of short-term cholecalciferol supplementation on biochemical and hematological parameters in mice. Methods. Male diabetic (alloxan, 60mg/kg i.v., 10 days) and non diabetic mice were supplemented with cholecalciferol for seven days. The following parameters were determined: serum levels of 25-hydroxyvitamin D, phosphorus, calcium, urea, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, red blood cell count, white blood cell count (WBC), hematocrit, hemoglobin, differential cell counts of peritoneal lavage (PeL), and bronchoalveolar lavage (BAL) fluids and morphological analysis of lung, kidney, and liver tissues. Results. Relative to controls, cholecalciferol supplementation increased serum levels of 25-hydroxyvitamin D, calcium, hemoglobin, hematocrit, and red blood cell counts and decreased leukocyte cell counts of PeL and BAL fluids in diabetic mice. Diabetic mice that were not treated with cholecalciferol had lower serum calcium and albumin levels and hemoglobin, WBC, and mononuclear blood cell counts and higher serum creatinine and urea levels than controls. Conclusion. Our results suggest that cholecalciferol supplementation improves the hematological parameters and reduces leukocyte migration into the PeL and BAL lavage of diabetic mice.en
dc.description.affiliationUniv Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Lab Immunoendocrinol,FCF, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Rheumatol Div, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespDepartment of Medicine, Rheumatology Division, Universidade Federal de São Paulo, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipPro-reitoria de Pesquisa da Universidade de Sao Paulo (PRP/USP, Projeto I and Novos Docentes)
dc.description.sponsorshipIDFAPESP: 2010/02272-0
dc.description.sponsorshipIDFAPESP: 2012/23998-4
dc.description.sponsorshipIDFAPESP: 2013/20904-1
dc.description.sponsorshipIDFAPESP: 2014/05214-1
dc.description.sponsorshipIDFAPESP: 2017/05100-4
dc.description.sponsorshipIDCNPq: 470523/2013-1
dc.description.sponsorshipIDCNPq: 301617/2016-3
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1155/2017/7651815
dc.identifier.citationBiomed Research International. London, v. , p. -, 2017.
dc.identifier.doi10.1155/2017/7651815
dc.identifier.fileWOS000399972200001.pdf
dc.identifier.issn2314-6133
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56315
dc.identifier.wosWOS:000399972200001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofBiomed Research International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleVitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Miceen
dc.typeinfo:eu-repo/semantics/article
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