The effects of ghrelin on GH, ACTH and cortisol release in thyrotoxicosis

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dc.contributor.authorNascif, Sergio Oliva [UNIFESP]
dc.contributor.authorCorrea-Silva, Silvia Regina [UNIFESP]
dc.contributor.authorSilva, Marcos Roberto da
dc.contributor.authorBorges, Maria Helena Senger
dc.contributor.authorLengyel, Ana Maria Judith [UNIFESP]
dc.contributor.authorMEDIMOND
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:27:11Z
dc.date.available2018-06-18T11:27:11Z
dc.date.issued2004-01-01
dc.description.abstractIn thyrotoxicosis there is an impaired GH response to several stimuli. Ghrelin is a potent GH secretagogue and it also induces ACTH and cortisol release in men. We evaluated the effects of ghrelin in 6 hyperthyroid patients and in 8 controls. In thyrotoxicosis peak GH (mu g/L; mean +/- SE) levels after ghrelin administration were significantly lower than those observed in controls (20.9 +/- 3.5 vs. 62.6 +/- 10.3). The same pattern was seen with AUC (mu g/L.120min) values (871 +/- 141 vs. 3667 +/- 662). ACTH and cortisol levels after ghrelin injection were similar in thyrotoxic patients and controls. In summary, our data shows that ghrelin-induced GH release is decreased in thyrotoxicosis, while ACTH and cortisol responsiveness is maintained. This could suggest that thyroid hormone excess interferes with GH releasing pathways activated by ghrelin.en
dc.description.affiliationUniv Fed Sao Paulo, Div Endocrinol, EPM, FAPESP,CNPq, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Endocrinol, EPM, FAPESP,CNPq, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent907-911
dc.identifier.citationProceedings Of The 12th International Congress Of Endocrinology. Bologna: Medimond Publishing Co, p. 907-911, 2004.
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45125
dc.identifier.wosWOS:000227355300154
dc.language.isoeng
dc.publisherMedimond Publishing Co
dc.relation.ispartofProceedings Of The 12th International Congress Of Endocrinology
dc.rightsAcesso restrito
dc.titleThe effects of ghrelin on GH, ACTH and cortisol release in thyrotoxicosisen
dc.typeTrabalho apresentado em evento
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