Conjunctival impression cytology evaluation of patients with dry eye disease using scleral contact lenses

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dc.citation.issue3
dc.citation.volume40
dc.contributor.authorWeber, Sarah La Porta [UNIFESP]
dc.contributor.authorHazarbassanov, Rossen Mihaylov [UNIFESP]
dc.contributor.authorNasare, Alex [UNIFESP]
dc.contributor.authorPereira Gomes, Jose Alvaro [UNIFESP]
dc.contributor.authorHofling-Lima, Ana Luisa [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-13T11:52:59Z
dc.date.available2020-07-13T11:52:59Z
dc.date.issued2017
dc.description.abstractPurpose: To evaluate conjunctival impression cytology and HLADR expression changes after wearing scleral contact lenses (ScCLs) for moderate to severe dry eye disease (DED). Design: Prospective interventional case series. Methods: Forty-one eyes from 25 patients with moderate to severe DED were evaluated for Esclera ScCL treatment. Best-corrected visual acuity (BCVA) and slit-lamp findings were assessed. Impression cytology specimens were obtained from DED patients at the baseline and after wearing ScCLs for 12 months. The impression cytology specimens were analyzed using morphological results score, and HLADR positive cells were detected and quantified. The values were compared to assess the IC changes after wearing ScCLs. Results: Forty-one eyes from 25 patients were fitted with ScCLs to manage DED. The underlying diseases were Stevens-Johnson syndrome (22 eyes), Sjogren's syndrome (11 eyes), graft-versus-host disease (2 eyes), dry eye after keratomileusis (2 eyes) and undifferentiated ocular surface disease (4 eyes). The HEPAS impression cytology score did not differ significantly before and after wearing ScCLs for 12 months in DED patients (p > 0.05). The percentage of eyes expressing the HLA-DR antigen in the temporal conjunctiva after wearing ScCL for 12 months significantly increased in patients with Sjogren's syndrome (11.11% to 66.66%en
dc.description.abstractp = 0.0498). In groups with Stevens Johnson syndrome and other ocular surface disorders, we did not observe statistically significant differences (p > 0.05). Conclusions: The ScCLs did not change the parameters used to evaluate inflammatory processes, which were measured using conjunctival impression cytology and HLA-DR expression, except in Sjogren syndrome, in which there was an unexpected increase in HLA expression. (C) 2016 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Ocular Surface Adv Ctr, 821 Botucatu St Vila Clementino, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Ocular Surface Adv Ctr, 821 Botucatu St Vila Clementino, BR-04023062 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent151-156
dc.identifierhttp://dx.doi.org/10.1016/j.clae.2016.12.008
dc.identifier.citationContact Lens & Anterior Eye. Amsterdam, v. 40, n. 3, p. 151-156, 2017.
dc.identifier.doi10.1016/j.clae.2016.12.008
dc.identifier.issn1367-0484
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54334
dc.identifier.wosWOS:000404489200004
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofContact Lens & Anterior Eye
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDry eye diseaseen
dc.subjectScleral contact lensen
dc.subjectImpression cytologyen
dc.subjectHLA-DRen
dc.subjectOcular surface inflammationen
dc.titleConjunctival impression cytology evaluation of patients with dry eye disease using scleral contact lensesen
dc.typeinfo:eu-repo/semantics/article
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