Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer

Página do item simplificado
dc.contributor.authorSiufi, Adalberto Abraao [UNIFESP]
dc.contributor.authorSilva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.contributor.authorDardes, Rita de Cássia de Maio [UNIFESP]
dc.contributor.authorTakita, Luiz Carlos [UNIFESP]
dc.contributor.authorLima, Geraldo Rodrigues de [UNIFESP]
dc.contributor.authorGoncalves, Wagner Jose [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:49:43Z
dc.date.available2018-06-15T17:49:43Z
dc.date.issued2003-12-01
dc.description.abstractThe cyclin-dependent kinase inhibitor, p27, has been shown to mediate cell growth arrest thereby significantly reducing the percentage of proliferating cells. It seems that p27 expression is essential for the control of normal endometrial proliferation, and reduced or absent p27 expression may be an important step in endometrial carcinogenesis. Our aim was to demonstrate the effects of tamoxifen therapy on the expression of p27 protein in the endometrium of postmenopausal breast cancer patients. Fifty-three pre- and post-tamoxifen treatment endometrium samples were examined immunohistochemically using p27 antibody. Tamoxifen therapy (20 mg/day) for 60 days increased the expression of p27 protein in the endometrium of postmenopausal breast cancer patients. We conclude that tamoxifen therapy does not seem to be directly involved in the carcinogenesis of endometrial carcinoma since the expression of p27 is not decreased.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Gynecol, BR-04023061 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Gynecol, BR-04023061 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent1545-1551
dc.identifierhttps://doi.org/10.3892/ijo.23.6.1545
dc.identifier.citationInternational Journal Of Oncology. Athens: Professor D A Spandidos, v. 23, n. 6, p. 1545-1551, 2003.
dc.identifier.doi10.3892/ijo.23.6.1545
dc.identifier.issn1019-6439
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44091
dc.identifier.wosWOS:000186674200008
dc.language.isoeng
dc.publisherProfessor D A Spandidos
dc.relation.ispartofInternational Journal Of Oncology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectendometriumen
dc.subjecttamoxifenen
dc.subjectp27en
dc.titleEffects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast canceren
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos