Dopamine Transporter Shown by SPECT in Patients with Periodic Leg Movement after Acute Physical Exercise

Página do item simplificado
dc.contributor.authorCavagnolli, Daniel Alves [UNIFESP]
dc.contributor.authorEsteves, Andrea Maculano [UNIFESP]
dc.contributor.authorCastiglione, Mario Luiz Vieira [UNIFESP]
dc.contributor.authorBatista, Ilza Rosa [UNIFESP]
dc.contributor.authorBressan, Rodrigo Afonseca [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:10Z
dc.date.available2016-01-24T14:31:10Z
dc.date.issued2013-02-01
dc.description.abstractCAVAGNOLLI, D. A., A. M. ESTEVES, M. L. V. CASTIGLIONE, I. R. BATISTA, R. A. BRESSAN, S. TUFIK, and M. T. de MELLO. Dopamine Transporter Shown by SPECT in Patients with Periodic Leg Movement after Acute Physical Exercise. Med. Sci. Sports Exerc., Vol. 45, No. 2, pp. 224-229, 2013. Purpose: This study aimed to evaluate dopamine transporter (DAT) density in patients with periodic leg movement (PLM) shown by [Tc-99m]TRODAT-1 single-photon emission computed tomography (SPECT) imaging and to determine the influence of acute physical exercise (maximal exercise test [MET]) on DAT densities. Methods: Sixteen healthy male volunteers between 45 and 65 yr of age were selected to participate in the study. Each subject (eight subjects in the control group and eight subjects in the patients with PLM experimental group) underwent baseline polysomnography (PSG) to evaluate sleep patterns and PLM index values. After obtaining PSG baselines, SPECT baselines were determined using [Tc-99m]TRODAT-1, a selective DAT imaging ligand. Subsequently, the volunteers performed the MET in the morning, followed by a SPECT 2 h later and PSG that night to assess the effect of acute physical exercise on DAT and sleep patterns. Results: the baseline SPECT results showed marginally significantly lower DAT densities in the striatal region of the experimental group. After the MET, no significant differences were observed between groups. the results also showed a significant reduction in the PLM index in the experimental group and a significantly increased percentage of stage 1 non-REM sleep in both groups after MET. Conclusions: Our results show that patients with PLM had a marginally lower DAT density in the left putamen region compared with the control group. Although the effect of acute physical exercise (MET) reduced PLM symptoms, the results suggest that this improvement was not due to DAT availability.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04020050 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Fac Sci Appl, BR-04020050 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Interdisciplinary Lab Clin Neurosci, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Fac Sci Appl, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Interdisciplinary Lab Clin Neurosci, BR-04020050 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2008/03319-0-DAC
dc.description.sponsorshipIDFAPESP: CEPID 98/143033-ST
dc.format.extent224-229
dc.identifierhttp://dx.doi.org/10.1249/MSS.0b013e318270306c
dc.identifier.citationMedicine and Science in Sports and Exercise. Philadelphia: Lippincott Williams & Wilkins, v. 45, n. 2, p. 224-229, 2013.
dc.identifier.doi10.1249/MSS.0b013e318270306c
dc.identifier.issn0195-9131
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35899
dc.identifier.wosWOS:000313724300002
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMedicine and Science in Sports and Exercise
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDOPAMINE TRANSPORTERen
dc.subjectPHYSICAL EXERCISEen
dc.subjectPLMen
dc.subjectMAXIMAL EXERCISE TESTen
dc.titleDopamine Transporter Shown by SPECT in Patients with Periodic Leg Movement after Acute Physical Exerciseen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral