Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure

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dc.citation.issue6
dc.citation.volume32
dc.contributor.authorda Conceicao, Rodrigo Rodrigues [UNIFESP]
dc.contributor.authorde Souza, Janaina Sena [UNIFESP]
dc.contributor.authorde Oliveira, Kelen Carneiro [UNIFESP]
dc.contributor.authorde Barros Maciel, Rui Monteiro [UNIFESP]
dc.contributor.authorRomano, Marco Aurelio
dc.contributor.authorRomano, Renata Marino
dc.contributor.authorDias da Silva, Magnus Regios [UNIFESP]
dc.contributor.authorChiamolera, Maria Izabel [UNIFESP]
dc.contributor.authorGiannocco, Gisele [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-09-01T13:21:13Z
dc.date.available2020-09-01T13:21:13Z
dc.date.issued2017
dc.description.abstractThe aim of this study was to investigate the influence of Bisphenol A (BPA) exposure on Neuroglobin (Ngb) and Cytoglobin (Cygb) as well as oxidative stress gene expression in the cerebellum, hippocampus, hypothalamus and cortex. Male Wistar rats were randomly divided into 3 groups: Control and two groups receiving 2 different daily BPA dosages, 5 or 25 mg/kg from postnatal day 50 (PND50) through PND90 and they were euthanized at PND105. In the cortex, we found an increase in Ngb gene expression and also in superoxide dismutase 1 and Catalase (Cat). In the cerebellum, we found an increase in Ngb and Cat, in the hypothalamus, there was a decrease in Cygb and an increase in glutathione peroxidase and Cat and in hypoxia-inducible factor 1 alpha (Hif1 alpha) at the low dosage and a decrease in Hif1 alpha at the high BPA dosage. Finally, in the hippocampus, we observed a decrease in Ngb and Cygb and an increase in Hif1 alpha. In summary, BPA promotes the modulation of both Ngb and Cygb, but such changes occur by different mechanisms depending on the exposure dose and anatomical area.en
dc.description.affiliationUniv Fed Sao Paulo Unifesp, EPM, Lab Mol & Translat Endocrinol, Dept Med, Sao Paulo, SP, Brazil
dc.description.affiliationState Univ Ctr Oeste, Dept Pharm, Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biol Sci, Diadema, SP, Brazil
dc.description.affiliationUniv Fed So Paulo UNIFESP, Dept Med, Lab Endocriol Mol & Translac, Rua Pedro Toledo,Vila Clementino, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, EPM, Lab Mol & Translat Endocrinol, Dept Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biol Sci, Diadema, SP, Brazil
dc.description.affiliationUnifespUniv Fed So Paulo UNIFESP, Dept Med, Lab Endocriol Mol & Translac, Rua Pedro Toledo,Vila Clementino, BR-04039032 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenacao de Aperfeicoamento de pessoal de nivel superior (CAPES)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipCAPES - AUXPE Pro-integracao
dc.description.sponsorshipIDCAPES: 18952-12-7
dc.description.sponsorshipIDFAPESP: 2013/26851-7
dc.description.sponsorshipIDCAPES - AUXPE Pro-integracao: 3160/2013-98
dc.format.extent1843-1851
dc.identifierhttp://dx.doi.org/10.1007/s11011-017-0066-5
dc.identifier.citationMetabolic Brain Disease. New York, v. 32, n. 6, p. 1843-1851, 2017.
dc.identifier.doi10.1007/s11011-017-0066-5
dc.identifier.issn0885-7490
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58135
dc.identifier.wosWOS:000415225800007
dc.language.isoeng
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofMetabolic Brain Disease
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBisphenolaen
dc.subjectNeuroglobinen
dc.subjectCytoglobinen
dc.subjectReactive oxygen speciesen
dc.subjectBrainen
dc.titleAnatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposureen
dc.typeinfo:eu-repo/semantics/article
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